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Spurs vs. Cavaliers prediction: Cleveland to win, Donovan Mitchell projected for big game in Friday's NBA matchup [12/5/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get San Antonio Spurs vs Cleveland Cavaliers predictions for NBA Friday.
The Cleveland Cavaliers and San Antonio Spurs are scheduled to meet in NBA action at Rocket Arena on Friday, starting at 7:30PM ET.
Based on the latest simulation results and today’s injury reports, Dimers' proven NBA model predicts the Cavaliers as the most likely winner of the Spurs vs. Cavaliers game.
This prediction follows the latest NBA Injury Report, which suggests the Cavaliers lineup will feature stars like Donovan Mitchell, Evan Mobley and De'Andre Hunter, while the Spurs will be led by De'Aaron Fox, Devin Vassell and Harrison Barnes.
This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Spurs vs. Cavs prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the result of Friday's NBA matchup between the Spurs and Cavaliers 10,000 times as part of our NBA predictions coverage.
Our leading predictive model gives the Cavaliers a 63% chance of beating the Spurs. Our predicted final score has the Cavaliers winning 120-117.
According to our model, the bookmakers have got it right, and the Spurs and Cavaliers each have a 50% chance of covering the spread, while the 238.5-point over/under has a 53% chance of staying under.
Spurs vs. Cavaliers odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Spurs | Cavaliers |
|---|---|---|
| Spread | +4.5 (-115) | -4.5 (-105) |
| Moneyline | +142 | -162 |
| Total | o238.5 (-110) | u238.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Spurs vs. Cavaliers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Cavaliers -4.5 | -105 |
| Moneyline | Cavaliers | -162 |
| Total | Under 238.5 | -105 |
According to our best NBA bets for Friday, the top play to make on this game is Cavaliers to win.
Spurs vs. Cavaliers player props
Looking for San Antonio vs. Cleveland NBA prop bets? We use the best information available to project how each team's leading players will perform at Rocket Arena.
De'Aaron Fox is expected to lead the Spurs with 22 points, 4 rebounds and 6 assists, while Donovan Mitchell is projected to have 30 points, 5 rebounds and 6 assists for the Cavaliers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Spurs prediction
Our model's projected player stats for the Spurs are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| De'Aaron Fox | 22 | 4 | 6 | 2 | 42 |
| Devin Vassell | 15 | 4 | 3 | 2 | 29 |
| Harrison Barnes | 15 | 4 | 2 | 3 | 27 |
| Keldon Johnson | 14 | 6 | 2 | 1 | 29 |
| Dylan Harper | 13 | 3 | 4 | 1 | 25 |
Cavaliers prediction
Projected points, rebounds, assists and three-pointers made for the Cavaliers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| D. Mitchell | 30 | 5 | 6 | 4 | 53 |
| Evan Mobley | 19 | 9 | 4 | 2 | 44 |
| De'Andre Hunter | 18 | 5 | 2 | 3 | 32 |
| Jaylon Tyson | 14 | 6 | 3 | 2 | 31 |
| Nae'Qwan Tomlin | 10 | 4 | 1 | 1 | 20 |
Spurs vs. Cavs game-day updates and essential details
Friday's matchup between the Cavaliers and Spurs at Rocket Arena is scheduled to start at 7:30PM ET.
- Who: San Antonio Spurs vs. Cleveland Cavaliers
- Date: Friday, December 5, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: Rocket Arena
Conclusion
We predict the Cavaliers, with a 63% win probability, will likely beat the Spurs on Friday, with Donovan Mitchell projected for a game-high 53 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Spurs vs. Cavaliers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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