Spurs vs. Cavaliers prediction: Cleveland to win, Donovan Mitchell projected for big game in Friday's NBA matchup [12/5/2025]

NBA action continues on Friday at 7:30PM ET as the San Antonio Spurs lock horns with the Cleveland Cavaliers at Rocket Arena.

Based on updated simulations and today’s injury reports, Dimers' proven NBA model projects the Cavaliers as the most likely winner of the Spurs vs. Cavaliers game.

This prediction follows the latest NBA Injury Report, which suggests the Cavaliers lineup will feature stars like Donovan Mitchell, Evan Mobley and De'Andre Hunter, while the Spurs will rely on De'Aaron Fox, Harrison Barnes and Devin Vassell.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Spurs vs. Cavs prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Friday's NBA matchup between the Spurs and Cavaliers 10,000 times as part of our NBA predictions coverage.

Our leading predictive model gives the Cavaliers a 65% chance of beating the Spurs. Our predicted final score has the Cavaliers winning 121-116.

According to our model, the Cavaliers (-5.5) have a 52% chance of covering the spread, while the over/under total of 239.5 points has a 53% chance of staying under.

Spurs vs. Cavaliers odds

We have researched the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Spurs vs. Cavaliers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Friday, the top play to make on this game is Under 239.5 total points.

Spurs vs. Cavaliers player props

NBA prop bets are an exciting way to wager on Friday's Spurs vs. Cavaliers game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at Rocket Arena.

De'Aaron Fox is expected to lead the Spurs with 22 points, 4 rebounds and 6 assists, while Donovan Mitchell is projected to have 31 points, 5 rebounds and 6 assists for the Cavaliers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Spurs prediction

Our model's projected player stats for the Spurs are:

Cavaliers prediction

Projected points, rebounds, assists and three-pointers made for the Cavaliers:

Spurs vs. Cavs game-day updates and essential details

Friday's matchup between the Cavaliers and Spurs at Rocket Arena is scheduled to begin at 7:30PM ET.

• Who: San Antonio Spurs vs. Cleveland Cavaliers
• Date: Friday, December 5, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Rocket Arena

Conclusion

We predict the Cavaliers, with a 65% win probability, will likely beat the Spurs on Friday, with Donovan Mitchell projected for a game-high 53 fantasy points.

AI and automation have enhanced this article to quickly deliver accurate Spurs vs. Cavaliers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.