Saint Louis vs. VCU prediction: Virginia Commonwealth favored to win men's college basketball matchup [1/7/2026]

VCU will square off with Saint Louis in men's college basketball action at Stuart C. Siegel Center on Wednesday, starting at 7:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Virginia Commonwealth as the most likely winner of the Saint Louis vs. VCU game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Louis vs. VCU prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between Saint Louis and VCU 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Virginia Commonwealth a 60% chance of beating Saint Louis. Our predicted final score has Virginia Commonwealth winning 82-79.

According to our model, Virginia Commonwealth (-2.5) has a 51% chance of covering the spread, while the 170.5-point over/under has a 56% chance of staying under.

Saint Louis vs. VCU odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Louis vs. VCU picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: