Saint Louis vs. Loyola Chicago prediction: Saint Louis favored to win men's college basketball matchup [2/13/2026]

Loyola Chicago will square off with the favored Saint Louis in men's college basketball action at Joseph J. Gentile Arena on Friday, commencing at 8:30 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Saint Louis as the most likely winner of the Saint Louis vs. Loyola Chicago game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Louis vs. Loyola Chicago prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Friday's NCAA basketball matchup between Saint Louis and Loyola Chicago 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Saint Louis a 91% chance of beating Loyola Chicago. Our predicted final score has Saint Louis winning 83-67.

According to our model, Loyola Chicago (+17.5) has a 54% chance of covering the spread, while the 155.5-point over/under has a 55% chance of staying under.

Saint Louis vs. Loyola Chicago odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Louis vs. Loyola Chicago picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Under 155.5 total points.

Saint Louis vs. Loyola Chicago game-day updates and essential details

Friday's men's college basketball matchup between Loyola Chicago and Saint Louis at Joseph J. Gentile Arena is scheduled to start at 8:30 PM ET.

• Who: Saint Louis vs. Loyola Chicago
• Date: Friday, February 13, 2026
• Time: 8:30 PM ET/5:30PM PT
• Venue: Joseph J. Gentile Arena

Conclusion

We predict Saint Louis, with a 91% win probability, will likely beat Loyola Chicago on Friday.

AI and automation have enhanced this article to quickly deliver accurate Saint Louis vs. Loyola Chicago insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.