Saint Louis vs. La Salle prediction: Saint Louis favored to win men's college basketball matchup [1/10/2026]

La Salle will square off with the favored Saint Louis in men's college basketball action at John Glaser Arena on Saturday, beginning at 4:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Saint Louis as the most likely winner of the Saint Louis vs. La Salle game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Louis vs. La Salle prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Saint Louis and La Salle 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Saint Louis a 92% chance of defeating La Salle. Our predicted final score has Saint Louis winning 83-67.

According to our model, La Salle (+16.5) has a 53% chance of covering the spread, while the 152.5-point over/under has a 52% chance of staying under.

Saint Louis vs. La Salle odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Louis vs. La Salle picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: