Saint Louis vs. Duquesne prediction: Saint Louis favored to win men's college basketball matchup [1/20/2026]

Duquesne will take on the favored Saint Louis in men's college basketball action at UPMC Cooper Fieldhouse on Tuesday, commencing at 7:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects Saint Louis as the most likely winner of the Saint Louis vs. Duquesne game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Louis vs. Duquesne prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Tuesday's NCAA basketball matchup between Saint Louis and Duquesne 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Saint Louis a 74% chance of beating Duquesne. Our predicted final score has Saint Louis winning 83-76.

According to our model, Duquesne (+8.5) has a 57% chance of covering the spread, while the 165.5-point over/under has a 54% chance of staying under.

Saint Louis vs. Duquesne odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Louis vs. Duquesne picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: