Purdue vs. USC prediction: Purdue favored to win men's college basketball matchup [1/17/2026]

Men's college basketball action continues on Saturday at 6:00 PM ET as the favored Purdue takes on USC in men's college basketball action at Galen Center.

Based on updated simulation results, Dimers' advanced college basketball model projects Purdue as the most likely winner of the Purdue vs. USC game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Purdue vs. USC prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball game between Purdue and USC 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Purdue a 75% chance of defeating USC. Our predicted final score has Purdue winning 82-74.

According to our model, USC (+9.5) has a 57% chance of covering the spread, while the over/under total of 155.5 points has a 52% chance of going over.

Purdue vs. USC odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Purdue vs. USC picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: