Purdue Fort Wayne vs. Notre Dame prediction: Notre Dame favored to win men's college basketball matchup [12/21/2025]

Men's college basketball action continues on Sunday at 2:00 PM ET as Purdue Fort Wayne locks horns with Notre Dame in men's college basketball action at Purcell Pavilion.

Based on the latest simulations, Dimers' advanced college basketball model predicts Notre Dame as the most likely winner of the Purdue Fort Wayne vs. Notre Dame game.

This article offers further insights into Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Purdue Fort Wayne vs. Notre Dame prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Sunday's NCAA basketball game between Purdue Fort Wayne and Notre Dame 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Notre Dame an 87% chance of beating Purdue Fort Wayne. Our predicted final score has Notre Dame winning 78-66.

According to our model, Purdue Fort Wayne (+11.5) has a 51% chance of covering the spread, while the over/under total of 145.5 points has a 55% chance of staying under.

Purdue Fort Wayne vs. Notre Dame odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Purdue Fort Wayne vs. Notre Dame picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: