Presbyterian vs. East Carolina prediction: Why East Carolina is favored to win men's college basketball matchup [12/17/2025]

East Carolina and Presbyterian will meet in men's college basketball action at Williams Arena at Minges Coliseum on Wednesday, with tipoff at 7:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts East Carolina as the most likely winner of the Presbyterian vs. East Carolina game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Presbyterian vs. East Carolina prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between Presbyterian and East Carolina 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives East Carolina a 66% chance of defeating Presbyterian. Our predicted final score has East Carolina winning 68-65.

According to our model, East Carolina (-3.5) has a 51% chance of covering the spread, while the 130.5-point over/under has a 55% chance of going over.

Presbyterian vs. East Carolina odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Presbyterian vs. East Carolina picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: