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Trail Blazers vs. Pistons prediction: Detroit favored to win Friday's NBA matchup [12/5/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Portland Trail Blazers vs Detroit Pistons predictions for NBA Friday.
NBA action continues on Friday at 7:30PM ET as the Portland Trail Blazers take on the Detroit Pistons at Little Caesars Arena.
Based on the latest simulations and today’s injury news, Dimers' proven NBA model predicts the Pistons as the most likely winner of the Trail Blazers vs. Pistons game.
This prediction follows the latest NBA Injury Report, which suggests the Pistons lineup will feature stars like Cade Cunningham, Jalen Duren and Tobias Harris, while the Trail Blazers will look to Deni Avdija, Shaedon Sharpe and Jerami Grant.
This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Blazers vs. Pistons prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Friday's NBA matchup between the Trail Blazers and Pistons 10,000 times as part of our NBA predictions coverage.
Our independent predictive model currently gives the Pistons a 71% chance of defeating the Trail Blazers. Our predicted final score has the Pistons winning 120-114.
According to our model, the Trail Blazers (+7.5) have a 54% chance of covering the spread, while the 235.5-point over/under has a 53% chance of staying under.
Trail Blazers vs. Pistons odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | Trail Blazers | Pistons |
|---|---|---|
| Spread | +7.5 (-108) | -7.5 (-108) |
| Moneyline | +245 | -300 |
| Total | o235.5 (-110) | u235.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Trail Blazers vs. Pistons picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Trail Blazers +7.5 | -108 |
| Moneyline | Trail Blazers | +245 |
| Total | Under 235.5 | -110 |
According to our best NBA bets for Friday, the top play to make on this game is Trail Blazers +7.5 at the spread.
Trail Blazers vs. Pistons player props
NBA prop bets are a popular way to wager on the Trail Blazers vs. Pistons matchup without necessarily betting on the outcome. We use the best information available to project how each team's leading players will perform at Little Caesars Arena.
Deni Avdija is expected to lead the Trail Blazers with 24 points, 8 rebounds and 6 assists, while Cade Cunningham is projected to have 29 points, 7 rebounds and 8 assists for the Pistons.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Trail Blazers prediction
Our model's projected player stats for the Trail Blazers are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Deni Avdija | 24 | 8 | 6 | 2 | 50 |
| Shaedon Sharpe | 19 | 4 | 3 | 2 | 34 |
| Jerami Grant | 18 | 4 | 3 | 2 | 33 |
| Toumani Camara | 14 | 6 | 3 | 3 | 33 |
| Donovan Clingan | 9 | 10 | 2 | 1 | 30 |
Pistons prediction
Projected points, rebounds, assists and three-pointers made for the Pistons:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Cade Cunningham | 29 | 7 | 8 | 2 | 58 |
| Jalen Duren | 17 | 11 | 3 | 0 | 41 |
| Tobias Harris | 13 | 5 | 2 | 1 | 27 |
| Duncan Robinson | 12 | 3 | 3 | 3 | 23 |
| Ausar Thompson | 12 | 7 | 3 | 0 | 30 |
Blazers vs. Pistons game-day updates and essential details
Friday's game between the Pistons and Trail Blazers at Little Caesars Arena is scheduled to commence at 7:30PM ET.
- Who: Portland Trail Blazers vs. Detroit Pistons
- Date: Friday, December 5, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: Little Caesars Arena
Conclusion
We predict the Pistons, with a 71% win probability, will likely beat the Trail Blazers on Friday, with Cade Cunningham projected for a game-high 58 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Trail Blazers vs. Pistons insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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