Portland State vs. Colorado prediction: Why Colorado is favored to win men's college basketball matchup [12/17/2025]

Colorado and Portland State are scheduled to meet in men's college basketball action at CU Events Center on Wednesday, starting at 9:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Colorado as the most likely winner of the Portland State vs. Colorado game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Portland State vs. Colorado prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball matchup between Portland State and Colorado 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Colorado a 92% chance of beating Portland State. Our predicted final score has Colorado winning 84-68.

According to our model, the bookmakers have got it right, and Portland State and Colorado each have a 50% chance of covering the spread, while the 149.5-point over/under has a 55% chance of going over.

Portland State vs. Colorado odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Portland State vs. Colorado picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: