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Steelers vs. Lions prediction: Detroit favored to win in NFL Week 16 [2025]

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Written by Jason Bevilacqua

Get Pittsburgh Steelers vs Detroit Lions predictions for NFL Sunday.

Pittsburgh Steelers-Detroit Lions Predictions and Game Preview.
Pittsburgh Steelers vs. Detroit Lions NFL prediction for Sunday, December 21, 2025.

The Detroit Lions will face the Pittsburgh Steelers in NFL Week 16 action at Ford Field on Sunday, starting at 4:25 PM ET.

Based on the latest simulations, Dimers' advanced NFL model predicts the Lions as the most likely winner of the Steelers vs. Lions game.

This article offers a closer look at Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.

Steelers vs. Lions prediction: Who will win and cover?

Since our Steelers-Lions predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Steelers and Lions 10,000 times as part of our NFL predictions coverage.

Our leading predictive model gives the Lions a 71% chance of beating the Steelers in Week 16 of the NFL season. Our predicted final score has the Lions winning 28-22.

According to our model, the Steelers (+7.5) have a 54% chance of covering the spread, while the over/under total of 52.5 points has a 53% chance of staying under.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 16 straight up picks.

Steelers vs. Lions odds

We have researched the best NFL odds in America for this game, which are listed here:

Bet Type Steelers Lions
Spread +7.5 (-115) -7.5 (-105)
Moneyline +300 -370
Total o52.5 (-105) u52.5 (-115)

All odds are correct at the time of publication and are subject to change.

Steelers vs. Lions picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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