NFL picks straight up: Week 16, 2025

At Dimers, our Week 16 NFL picks are grounded in data-driven insight, with straight-up picks for all 16 games informed by our latest NFL predictions.

Gain the edge in your NFL pick 'em contests by following our data-driven NFL Week 16 picks straight up, powered by thousands of game simulations.

Week 16 of the NFL season begins with the Los Angeles Rams facing the Seattle Seahawks on Thursday night and ends with the San Francisco 49ers taking on the Indianapolis Colts on Monday night.

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Full list of NFL Week 16 picks straight up

• Rams (57% win probability)
• Eagles (68%)
• Packers (59%)
• Bills (85%)
• Cowboys (60%)
• Saints (67%)
• Buccaneers (62%)
• Vikings (58%)
• Chiefs (64%)
• Bengals (58%)
• Broncos (59%)
• Falcons (56%)
• Texans (93%)
• Lions (72%)
• Ravens (57%)
• 49ers (67%)

NFL picks this week straight up: Week 16, 2025

Listed below are our Week 16 NFL picks, highlighting how likely each team is to win their game this week.

Los Angeles Rams vs. Seattle Seahawks

The Rams kick off Week 16 against the Seahawks at Lumen Field on Thursday night. According to our model, the Rams have a 57% chance of winning, while the Seahawks have a 43% chance.

For Week 16's opening game, our model highlights NFL player props with Kyren Williams (RB) as the most likely player from the Rams to score the first TD at 12.1%, while Jaxon Smith-Njigba (WR) is the top candidate from the Seahawks at 11.5%.

The Los Angeles Rams vs. Seattle Seahawks game at Lumen Field is scheduled for Thursday, December 18 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Philadelphia Eagles vs. Washington Commanders

For this week's game between the Eagles and the Commanders, Philadelphia is more likely to win. Our prediction model gives the Eagles a 68% chance of winning. On the other hand, there is a 32% chance that the Commanders will win.

The Philadelphia Eagles vs. Washington Commanders matchup at Northwest Stadium will take place on Saturday, December 20 at 5:00pm.

As the playoffs apporoach, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Green Bay Packers vs. Chicago Bears

We are picking the Packers to win their game against the Bears this week, with our trusted NFL model projecting a 59% win probability for the road team. The Bears have a 41% chance of winning at Soldier Field.

For betting purposes, the Bears are listed as +1.5 underdogs, with the Packers' moneyline at -112.

The Green Bay Packers vs. Chicago Bears game at Soldier Field is slated for Saturday, December 20 at 8:20pm.

Buffalo Bills vs. Cleveland Browns

According to our predictive analytics model, the Bills are the team to beat in this game, with their win probability at 85%. The Browns, on the other hand, have a 15% chance of winning.

The Buffalo Bills vs. Cleveland Browns game at Huntington Bank Field is set for Sunday, December 21 at 1:00pm.

Los Angeles Chargers vs. Dallas Cowboys

The Cowboys have a 60% chance of winning on Sunday afternoon, compared to the Chargers' 40% chance of victory. This makes the Dallas Cowboys our pick to win at AT&T Stadium.

The Los Angeles Chargers vs. Dallas Cowboys matchup at AT&T Stadium is scheduled for Sunday, December 21 at 1:00pm.

New York Jets vs. New Orleans Saints

The Saints are favorites to win this one, with our predictive analytics model giving them a 67% chance, while the Jets enter the weekend with a 33% chance of causing an upset at Caesars Superdome.

When it comes to betting on this game, the Jets' moneyline odds are set at +185, with the home team Saints listed as -4 favorites.

The New York Jets vs. New Orleans Saints game at Caesars Superdome will take place on Sunday, December 21 at 1:00pm.

Tampa Bay Buccaneers vs. Carolina Panthers

After 10,000 simulations of Buccaneers vs. Panthers this Sunday, our model projects the Buccaneers as the more likely winners with a probability of 62%. Their opponents, the Panthers, have a 38% chance of getting the win at home.

The Tampa Bay Buccaneers vs. Carolina Panthers matchup at Bank of America Stadium is slated for Sunday, December 21 at 1:00pm.

Minnesota Vikings vs. New York Giants

We are picking the Vikings, who have a 58% chance of winning the matchup, while the Giants have a 42% win probability.

The Minnesota Vikings vs. New York Giants game at MetLife Stadium will take place on Sunday, December 21 at 1:00pm.

Kansas City Chiefs vs. Tennessee Titans

The next game of Week 16 sees the Chiefs take on the Titans at Nissan Stadium.

We predict the Chiefs to win with a probability of 64%, while the Titans are projected to have a win chance of 36%.

As for the Vegas betting odds here, the Titans are listed as +3.5 underdogs, with the Chiefs' moneyline odds posted at -190.

The Kansas City Chiefs vs. Tennessee Titans game at Nissan Stadium is scheduled for Sunday, December 21 at 1:00pm.

Cincinnati Bengals vs. Miami Dolphins

The likely winner of this matchup is the Bengals, who have a projected win chance of 58%, according to DimersBOT. On the other side of this matchup, the Dolphins have a projected win probability of 42%.

The Cincinnati Bengals vs. Miami Dolphins matchup at Hard Rock Stadium is set for Sunday, December 21 at 1:00pm.

Jacksonville Jaguars vs. Denver Broncos

We have run our powerful NFL model over this week’s Jaguars-Broncos clash 10,000 times, with the Broncos coming out as the team to pick. Of those 10,000 simulations, the Broncos won 5,891 times, with the Jaguars winning on 4,109 occasions.

The Jacksonville Jaguars vs. Denver Broncos game at Empower Field at Mile High is scheduled for Sunday, December 21 at 4:05pm.

Atlanta Falcons vs. Arizona Cardinals

Next up is the game between the Falcons and Cardinals, with our model projecting the road team as the more likely victor, with the Falcons rated as having a 56% chance of getting the W. The Cardinals, on the other hand, are projected to have a 44% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Falcons' moneyline odds set at -140 for this road game, while the hosting Cardinals are listed as +2.5 underdogs.

The Atlanta Falcons vs. Arizona Cardinals game at State Farm Stadium will take place on Sunday, December 21 at 4:05pm.

Las Vegas Raiders vs. Houston Texans

Our next straight up pick this week is for the Texans to get the win against the Raiders. After running 10,000 simulations of this matchup, the Houston have a win probability of 93%, with the Raiders at 7%.

The Las Vegas Raiders vs. Houston Texans game at NRG Stadium is slated for Sunday, December 21 at 4:25pm.

Pittsburgh Steelers vs. Detroit Lions

With a win probability of 72% on Sunday afternoon, our straight up pick for this matchup is the Lions, while their opponent, the Steelers, have a projected win chance of 28%.

The Pittsburgh Steelers vs. Detroit Lions game at Ford Field will take place on Sunday, December 21 at 4:25pm.

For a different angle on this week's NFL action, explore our NFL trends to spot the latest player prop trends.

New England Patriots vs. Baltimore Ravens

The team to pick here is the Ravens, who have a 57% chance of winning their matchup against the Patriots this Sunday night.

Looking at the betting odds for this Sunday Night Football clash, the Ravens are listed as -2.5 favorites at home, with the Patriots' moneyline odds available at +130.

The New England Patriots vs. Baltimore Ravens game at M&T Bank Stadium is scheduled for Sunday, December 21 at 8:20pm.

San Francisco 49ers vs. Indianapolis Colts

Our pick to win the final game of Week 16 is the 49ers, who have a win probability of 67%. Their opponents are projected to have a 33% chance of getting the W.

The San Francisco 49ers vs. Indianapolis Colts game at Lucas Oil Stadium is set for Monday, December 22 at 8:15pm.

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Week 16

The NFL Week 16 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.