Pirates vs. Cardinals Prediction: St. Louis Predicted to Win Wednesday's MLB Matchup [5/7/2025]

MLB action continues on Wednesday at 1:15PM ET as the Pittsburgh Pirates take on the St. Louis Cardinals at Busch Stadium.

The Cardinals will start Sonny Gray (3-1, 4.12 ERA), while the Pirates have opted for Mitch Keller (1-3, 4.38 ERA).

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Cardinals as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Pittsburgh-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Cardinals' chance of winning at 62%, with the Pirates at 38%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive Pirates vs. Cardinals predictions page.

Cardinals vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Pirates and Cardinals 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Cardinals a 62% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 56% chance of staying under.

Pirates vs. Cardinals Odds [5/7/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	Pirates	Cardinals
Run Line	+1.5 (-142)	-1.5 (+125)
Moneyline	+160	-175
Total	o8 (-102)	u8 (-125)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Pirates vs. Cardinals matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Pirates vs. Cardinals Game-Day Updates and Essential Details

Wednesday's MLB game between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 1:15PM ET.

• Who: Pittsburgh Pirates vs. St. Louis Cardinals
• Date: Wednesday, May 7, 2025
• Time: 1:15PM ET/10:15AM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Wednesday's Pirates vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Cardinals, with a 62% win probability, will likely beat the Pirates on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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