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Pirates vs. Padres Prediction: San Diego Predicted to Win Sunday's MLB Matchup [6/1/2025]

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Written by Dave Garofolo

Our expert prediction for Sunday's Pittsburgh Pirates vs San Diego Padres matchup.

Pittsburgh Pirates-San Diego Padres Predictions and Game Preview.
PETCO Park sets the stage for the MLB matchup between the Pittsburgh Pirates and San Diego Padres this Sunday.

The San Diego Padres will take on the Pittsburgh Pirates in MLB action at PETCO Park on Sunday, beginning at 5:10PM ET.

Randy Vásquez (3-4, 3.58 ERA) will be the starting pitcher for the Padres, pitting him against Andrew Heaney (3-4, 3.41 ERA) for the Pirates.

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Pittsburgh-San Diego game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 58%, while the Pirates have 42%."

For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Pirates vs. Padres predictions page.

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Padres vs. Pirates Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Pirates and Padres 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Padres a 58% chance of beating the Pirates.

According to our model, the Pirates (+1.5) have a 61% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.

Pre-Game Probabilities
Last Updated: 9:27PM, Jun 1
Moneyline
Over / Under
Run Line
Pirates
Win %
38%
62%
Get the best bets with Dimers Pro
See Matchup
Padres
Pirates PIT
Win %
38%
62%
See Matchup
Padres SD
Andrew Heaney 3-4, 3.41 ERA
Randy Vásquez 3-4, 3.58 ERA
Get the best bets with Dimers Pro

Pirates vs. Padres Odds [6/1/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type Pirates Padres
Run Line +1.5 (-165) -1.5 (+145)
Moneyline +130 -146
Total o8.5 (-115) u8.5 (-102)

All odds are correct at the time of publication and are subject to change.

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Pirates vs. Padres Picks and Best Bets

Our model's biggest edge in today's Pirates vs. Padres matchup is on the run line.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Pirates vs. Padres Game-Day Updates and Essential Details

Sunday's MLB matchup between the Padres and Pirates at PETCO Park is scheduled to begin at 5:10PM ET.

Dimers.com's in-depth preview of Sunday's Pirates vs. Padres matchup includes our prediction, picks and the latest betting odds.

Before making any Pittsburgh vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

Conclusion

We predict the Padres, with a 58% win probability, will likely beat the Pirates on Sunday.

AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest predictions for the World Series, American League, National League and each division.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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