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Pirates vs. Padres Prediction: San Diego Predicted to Win Sunday's MLB Matchup [6/1/2025]
Our expert prediction for Sunday's Pittsburgh Pirates vs San Diego Padres matchup.

The San Diego Padres will take on the Pittsburgh Pirates in MLB action at PETCO Park on Sunday, beginning at 5:10PM ET.
Randy Vásquez (3-4, 3.58 ERA) will be the starting pitcher for the Padres, pitting him against Andrew Heaney (3-4, 3.41 ERA) for the Pirates.
Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Padres as the most likely winner of today's game.
"Using the most recent data, our experts ran 10,000 simulations of Sunday's Pittsburgh-San Diego game," said Dimers' Chief Content Officer, Nick Slade.
"After accounting for recent updates and other variables, our prediction shows the Padres with a win probability of 58%, while the Pirates have 42%."
For expanded analysis of Sunday's matchup, including best bets and picks, visit our interactive Pirates vs. Padres predictions page.
Padres vs. Pirates Prediction: Who Will Win, Cover the Run Line?
Using innovative machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Pirates and Padres 10,000 times as part of our MLB predictions coverage.
Our leading predictive model currently gives the Padres a 58% chance of beating the Pirates.
According to our model, the Pirates (+1.5) have a 61% chance of covering the run line, while the 8.5-run over/under has a 51% chance of staying under.
Pirates vs. Padres Odds [6/1/2025]
We have researched the best MLB odds in America for this game, which are listed here:
Bet Type | Pirates | Padres |
---|---|---|
Run Line | +1.5 (-165) | -1.5 (+145) |
Moneyline | +130 | -146 |
Total | o8.5 (-115) | u8.5 (-102) |
All odds are correct at the time of publication and are subject to change.
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Pirates vs. Padres Picks and Best Bets
Our model's biggest edge in today's Pirates vs. Padres matchup is on the run line.
Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.
Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.
Calling Our Shot's Free ⚾️ Picks
Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.
Pirates vs. Padres Game-Day Updates and Essential Details
Sunday's MLB matchup between the Padres and Pirates at PETCO Park is scheduled to begin at 5:10PM ET.
- Who: Pittsburgh Pirates vs. San Diego Padres
- Date: Sunday, June 1, 2025
- Time: 5:10PM ET/2:10PM PT
- Venue: PETCO Park
Dimers.com's in-depth preview of Sunday's Pirates vs. Padres matchup includes our prediction, picks and the latest betting odds.
Before making any Pittsburgh vs. San Diego picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.
Key MLB Betting Guides and Insights
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Conclusion
We predict the Padres, with a 58% win probability, will likely beat the Pirates on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Pirates vs. Padres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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