Phillies vs. Guardians Prediction: Philadelphia Predicted to Win Saturday's MLB Matchup [5/10/2025]

The Cleveland Guardians will take on the Philadelphia Phillies, in what is expected to be a close MLB game, at Progressive Field on Saturday, beginning at 6:10PM ET.

Tanner Bibee (3-2, 4.26 ERA) will get the ball for the Guardians, up against Ranger Suárez (0-0, 17.18 ERA) for the Phillies.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Phillies as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Philadelphia-Cleveland game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Phillies are more likely to win, while the Guardians have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Phillies vs. Guardians predictions page.

Guardians vs. Phillies Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the result of Saturday's MLB game between the Phillies and Guardians 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Phillies a 54% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 59% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of going over.

Phillies vs. Guardians Odds [5/10/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Phillies	Guardians
Run Line	-1.5 (+130)	+1.5 (-152)
Moneyline	-130	+112
Total	o8 (-105)	u8 (-108)

All odds are correct at the time of publication and are subject to change.

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Phillies vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Phillies vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Phillies vs. Guardians Game-Day Updates and Essential Details

Saturday's MLB game between the Guardians and Phillies at Progressive Field is scheduled to start at 6:10PM ET.

• Who: Philadelphia Phillies vs. Cleveland Guardians
• Date: Saturday, May 10, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Saturday's Phillies vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Philadelphia vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Phillies, with a 54% win probability, will likely beat the Guardians on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Phillies vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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