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Eagles vs. Bills prediction: Buffalo favored to win in NFL Week 17 [2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Philadelphia Eagles vs Buffalo Bills predictions for NFL Sunday.
The Buffalo Bills and Philadelphia Eagles are scheduled to meet in Week 17 of the NFL season at Highmark Stadium on Sunday, with kickoff at 4:25 PM ET.
Based on updated simulation results, Dimers' proven NFL model predicts the Bills as the most likely winner of the Eagles vs. Bills game.
This article offers a closer look at this week's matchup, including projected touchdown scorers, best bets and player prop picks.
Eagles vs. Bills prediction: Who will win and cover?
Since our Eagles-Bills predictions earlier in the week, we have simulated the outcome of Sunday's NFL matchup between the Eagles and Bills 10,000 times as part of our NFL predictions coverage.
Our independent predictive model currently gives the Bills a 60% chance of beating the Eagles in Week 17 of the NFL season. Our predicted final score has the Bills winning 23-20.
According to our model, the Eagles (+3.5) have a 56% chance of covering the spread, while the over/under total of 45.5 points has a 53% chance of staying under.
To see win probabilities for every matchup this week, check out our expert NFL Week 17 straight up picks.
Eagles vs. Bills odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Eagles | Bills |
|---|---|---|
| Spread | +3.5 (-130) | -3.5 (-102) |
| Moneyline | +152 | -170 |
| Total | o45.5 (-105) | u45.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Eagles vs. Bills picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Eagles +3.5 | -130 |
| Moneyline | Eagles | +152 |
| Total | Under 45.5 | -115 |
According to our NFL best bets, the top play to make on this game is Eagles to win.
Eagles vs. Bills TD scorers
Who will score a touchdown in Eagles vs. Bills?
According to our list of touchdown scorer predictions for Week 17, James Cook is most likely to score an anytime touchdown in Eagles vs. Bills.
Our projections give Cook a 53.8% chance of scoring a TD at Highmark Stadium, while the running back is a 13.0% chance of scoring the first touchdown the game.
Anytime touchdown scorer predictions
Philadelphia Eagles
| Player | Anytime TD Probability |
|---|---|
| Saquon Barkley (RB) | 46.7% |
| Jalen Hurts (QB) | 42.1% |
| A.J. Brown (WR) | 33.2% |
| DeVonta Smith (WR) | 28.9% |
| Dallas Goedert (TE) | 27.5% |
Buffalo Bills
| Player | Anytime TD Probability |
|---|---|
| James Cook (RB) | 53.8% |
| Josh Allen (QB) | 44.5% |
| Khalil Shakir (WR) | 26.3% |
| Dawson Knox (TE) | 22.5% |
| Ty Johnson (RB) | 16.6% |
First touchdown scorer predictions
Philadelphia Eagles
| Player | First TD Probability |
|---|---|
| Saquon Barkley (RB) | 10.2% |
| Jalen Hurts (QB) | 8.9% |
| A.J. Brown (WR) | 6.6% |
| DeVonta Smith (WR) | 5.5% |
| Dallas Goedert (TE) | 5.2% |
Buffalo Bills
| Player | First TD Probability |
|---|---|
| James Cook (RB) | 13.0% |
| Josh Allen (QB) | 9.9% |
| Khalil Shakir (WR) | 5.1% |
| Dawson Knox (TE) | 4.3% |
| Ty Johnson (RB) | 3.1% |
Eagles vs Bills player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Eagles and Bills. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 17 games.
Quarterbacks
Of the starting quarterbacks, the Eagles' Jalen Hurts is projected for 190 passing yards, while the Bills' Josh Allen is expected to throw for 201 yards.
| Player | Proj. Pass Yards |
|---|---|
| Jalen Hurts (PHI) | 190 |
| Josh Allen (BUF) | 201 |
Eagles rushing
| Player | Proj. Rush Yards |
|---|---|
| Saquon Barkley | 82 |
| Jalen Hurts | 36 |
| Tank Bigsby | 13 |
Bills rushing
| Player | Proj. Rush Yards |
|---|---|
| James Cook | 93 |
| Josh Allen | 36 |
| Ty Johnson | 12 |
Eagles receiving
| Player | Proj. Rec. Yards |
|---|---|
| A.J. Brown | 64 |
| DeVonta Smith | 52 |
| Dallas Goedert | 36 |
| Saquon Barkley | 16 |
| Jahan Dotson | 14 |
Bills receiving
| Player | Proj. Rec. Yards |
|---|---|
| Khalil Shakir | 45 |
| Dawson Knox | 28 |
| Joshua Palmer | 24 |
| James Cook | 17 |
| Ty Johnson | 15 |
Eagles vs. Bills game-day updates and essential details
The NFL Week 17 matchup between the Bills and Eagles at Highmark Stadium is scheduled to commence at 4:25 PM ET.
- Who: Philadelphia Eagles vs. Buffalo Bills
- Date: Sunday, December 28, 2025
- Time: 4:25 PM ET/1:25PM PT
- Venue: Highmark Stadium
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Conclusion
We predict the Bills, with a 60% win probability, will likely beat the Eagles in Week 17 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Eagles vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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