76ers vs. Cavaliers prediction: Why Cleveland is favored to win Wednesday's NBA matchup [11/5/2025]

NBA action continues on Wednesday at 7:00PM ET as the Philadelphia 76ers lock horns with the Cleveland Cavaliers at Rocket Arena.

Based on updated simulation results and today’s injury updates, Dimers' proven NBA model predicts the Cavaliers as the most likely winner of the 76ers vs. Cavaliers game.

This prediction follows the latest NBA Injury Report, which suggests the Cavaliers lineup will feature players like Donovan Mitchell, Evan Mobley and Darius Garland, while the 76ers will look to Tyrese Maxey, Quentin Grimes and VJ Edgecombe.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Sixers vs. Sixers prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Wednesday's NBA matchup between the 76ers and Cavaliers 10,000 times as part of our NBA predictions coverage.

Our famous predictive model currently gives the Cavaliers an 83% chance of defeating the 76ers. Our predicted final score has the Cavaliers winning 122-111.

According to our model, the 76ers (+12.5) have a 53% chance of covering the spread, while the 234.5-point over/under has a 51% chance of staying under.

76ers vs. Cavaliers odds

We have sourced the best NBA odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

76ers vs. Cavaliers picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best NBA bets for Wednesday, the top play to make on this game is 76ers to win.

76ers vs. Cavaliers player props

Betting on 76ers vs. Cavaliers NBA player props? We use the best information available to project how each team's leading players will perform at Rocket Arena.

Tyrese Maxey is expected to lead the 76ers with 27 points, 3 rebounds and 7 assists, while Donovan Mitchell is projected to have 27 points, 4 rebounds and 6 assists for the Cavaliers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

76ers prediction

Our model's projected player stats for the 76ers are:

Cavaliers prediction

Projected points, rebounds, assists and three-pointers made for the Cavaliers:

Sixers vs. Cavs game-day updates and essential details

Wednesday's action between the Cavaliers and 76ers at Rocket Arena is scheduled to start at 7:00PM ET.

• Who: Philadelphia 76ers vs. Cleveland Cavaliers
• Date: Wednesday, November 5, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Rocket Arena

Conclusion

We predict the Cavaliers, with an 83% win probability, will likely beat the 76ers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Cavaliers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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