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76ers vs. Celtics prediction: Boston favored to win Wednesday's NBA game [10/22/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Philadelphia 76ers vs Boston Celtics predictions for NBA Wednesday.
The Boston Celtics and Philadelphia Sixers will meet in NBA action at TD Garden on Wednesday, starting at 7:30PM ET.
Based on the latest simulation results and today’s injury news, Dimers' advanced NBA model predicts the Celtics as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's 76ers-Celtics game 10,000 times," said Damien Souness from Dimers.
"With the latest updates and numerous other variables, we estimate the Celtics' chance of winning at 71%, with the 76ers at 29%."
This prediction follows the latest NBA Injury Report, which suggests the Celtics lineup will feature players like Jaylen Brown, Derrick White and Anfernee Simons, while the 76ers will look to Tyrese Maxey, Joel Embiid and Quentin Grimes.
For a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive 76ers vs. Celtics predictions page.
Sixers vs. Sixers prediction: Who will win, cover the spread?
Using innovative machine learning and data, we have simulated the result of Wednesday's NBA matchup between the 76ers and Celtics 10,000 times as part of our NBA predictions coverage.
Our famous predictive model currently gives the Celtics a 71% chance of beating the 76ers. Our predicted final score has the Celtics winning 118-112.
According to our model, the Celtics (-5.5) have a 51% chance of covering the spread, while the 230.5-point over/under has an equal 50-50 chance of hitting.
76ers vs. Celtics odds
We have researched the best NBA odds in America for this game, which are listed here:
| Bet Type | 76ers | Celtics |
|---|---|---|
| Spread | +5.5 (-110) | -5.5 (-108) |
| Moneyline | +170 | -198 |
| Total | o230.5 (-108) | u230.5 (-110) |
All odds are correct at the time of publication and are subject to change.
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76ers vs. Celtics picks and best bets
Our model's strongest edge in today's 76ers vs. Celtics matchup is on the moneyline.
Our expert predictions, aligned with the current odds, reveal the best NBA picks and NBA best bets for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
76ers vs. Celtics player props
NBA prop bets are a great way to wager on the Philadelphia vs. Boston game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at TD Garden.
Tyrese Maxey is expected to lead the 76ers with 23 points, 3 rebounds and 6 assists, while Jaylen Brown is projected to have 23 points, 7 rebounds and 5 assists for the Celtics.
Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.
Sixers vs. Celtics game-day updates and essential details
Wednesday's game between the Celtics and 76ers at TD Garden is scheduled to begin at 7:30PM ET.
- Who: Philadelphia 76ers vs. Boston Celtics
- Date: Wednesday, October 22, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: TD Garden
Dimers' full preview of Wednesday's 76ers vs. Celtics matchup includes our prediction, picks and the latest betting odds.
Before making any Sixers vs. Celtics picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.
Conclusion
We predict the Celtics, with a 71% win probability, will likely beat the 76ers on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate 76ers vs. Celtics insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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