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Pepperdine vs. USC prediction: USC favored to win Black Friday women's college basketball matchup [11/28/2025]

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Written by Ryan Leaver

Get Pepperdine vs USC predictions for college basketball Friday.

Pepperdine-USC Predictions and Game Preview.
Pepperdine vs. USC women's college basketball prediction for Friday, November 28, 2025.

USC will face Pepperdine in women's college basketball Black Friday action at Galen Center on Friday, beginning at 5:00PM ET.

Based on updated simulations, Dimers' new women's basketball model predicts USC as the most likely winner of the Pepperdine vs. USC game.

This article offers an expanded analysis of Friday's matchup, including best bets and picks.

Pepperdine vs. USC prediction: Who will win?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's women's basketball game between Pepperdine and USC 10,000 times as part of our women's college basketball predictions coverage.

Our famous predictive model gives USC a 99% chance of defeating Pepperdine.

According to our model, the 131.5-point over/under has a 53% chance of staying under.

 

Pepperdine vs. USC odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

Bet Type Pepperdine USC
Spread +42.5 (-110) -42.5 (-110)
Total o131.5 (-110) u131.5 (-110)

All odds are correct at the time of publication and are subject to change.

Pepperdine vs. USC picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Pepperdine +42.5 -110
Total Under 131.5 -110

According to our women's college basketball best bets, the top play to make on this game is under 131.5 points.

 

Pepperdine vs. USC game-day updates and essential details

Friday's women's basketball matchup between USC and Pepperdine at Galen Center is scheduled to begin at 5:00PM ET.

  • Who: Pepperdine vs. USC
  • Date: Friday, November 28, 2025 (Black Friday)
  • Time: 5:00PM ET/2:00PM PT
  • Venue: Galen Center

 

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Conclusion

We predict USC, with a 99% win probability, will likely beat Pepperdine on Black Friday.

AI and automation have enhanced this article to quickly deliver accurate Pepperdine vs. USC insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Ryan Leaver
Senior Sports and Betting Editor

Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.

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