Pepperdine vs. Portland prediction: Why Portland is favored to win men's college basketball matchup [2/18/2026]

Portland and Pepperdine will lock horns in men's college basketball action at Chiles Center on Wednesday, starting at 10:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Portland as the most likely winner of the Pepperdine vs. Portland game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Pepperdine vs. Portland prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Wednesday's NCAA basketball matchup between Pepperdine and Portland 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Portland a 77% chance of beating Pepperdine. Our predicted final score has Portland winning 78-70.

According to our model, the bookmakers have got it right, and Pepperdine and Portland each have a 50% chance of covering the spread, while the over/under total of 150.5 points has a 53% chance of staying under.

Pepperdine vs. Portland odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pepperdine vs. Portland picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: