Pepperdine vs. Gonzaga prediction: Gonzaga favored to win men's college basketball matchup [1/21/2026]

Gonzaga and Pepperdine will lock horns in men's college basketball action at McCarthey Athletic Center on Wednesday, starting at 9:00 PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Gonzaga as the most likely winner of the Pepperdine vs. Gonzaga game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Pepperdine vs. Gonzaga prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between Pepperdine and Gonzaga 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Gonzaga a 98% chance of beating Pepperdine. Our predicted final score has Gonzaga winning 89-62.

According to our model, the bookmakers have got it right, and Pepperdine and Gonzaga each have a 50% chance of covering the spread, while the over/under total of 150.5 points has a 53% chance of going over.

Pepperdine vs. Gonzaga odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Pepperdine vs. Gonzaga picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Over 150.5 total points.

Pepperdine vs. Gonzaga game-day updates and essential details

Wednesday's men's college basketball matchup between Gonzaga and Pepperdine at McCarthey Athletic Center is scheduled to begin at 9:00 PM ET.

• Who: Pepperdine vs. Gonzaga
• Date: Wednesday, January 21, 2026
• Time: 9:00 PM ET/6:00PM PT
• Venue: McCarthey Athletic Center

Conclusion

We predict Gonzaga, with a 98% win probability, will likely beat Pepperdine on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Pepperdine vs. Gonzaga insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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