Penn State vs. Purdue prediction: Why Purdue is favored to win men's college basketball matchup [1/10/2026]

Men's college basketball action continues on Saturday at 2:00 PM ET as Penn State takes on Purdue in men's college basketball action at Mackey Arena.

Based on updated simulations, Dimers' advanced college basketball model predicts Purdue as the most likely winner of the Penn State vs. Purdue game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Penn State vs. Purdue prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Penn State and Purdue 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Purdue a 97% chance of defeating Penn State. Our predicted final score has Purdue winning 87-64.

According to our model, Purdue (-22.5) has a 52% chance of covering the spread, while the 152.5-point over/under has an equal 50-50 chance of hitting.

Penn State vs. Purdue odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Penn State vs. Purdue picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: