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Parlay these 49ers vs. Colts player props at +385 odds for Monday Night Football
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Reviewed by Nick Slade
Week 16 draws to a close in a battle between the 49ers and Colts
Monday Night Football closes out Week 16 with a matchup that feels lopsided on paper, as the surging 49ers take on a Colts team searching for answers. San Francisco have locked in a playoff spot, while the Colts appear to be unraveling following a wave of injuries and inconsistent play on both sides of the ball. With San Francisco expected to control this game, the betting angles line up around their star playmakers doing damage through the air — and the Colts being forced to respond earlier than they’d like, we've put together a three-leg parlay to see us through.
Our Monday Night Football parlay comes to +385 odds over on DraftKings Sportsbook, where new users can claim a $200 bonus when they sign up.
+385 49ers vs. Colts NFL Same Game Parlay Picks
After simulating tonight's game over 10,000 times, our model has identified the following projections and probabilities for the picks that make up our three-leg same game parlay in 49ers vs. Colts on Monday Night Football, December 21.
| Player | Prop | Projection |
|---|---|---|
| George Kittle (49ers) | 60+ Receiving Yards | 66 Rec Yds |
| Christian McCaffrey (49ers) | 40+ Receiving Yards | 41 Rec Yds |
| Philip Rivers (Colts) | 150+ Pass Yards | 181 Pass Yds |
MORE: 49ers vs. Colts MNF Full Game Betting Preview
Leg 1: George Kittle 60+ Receiving Yards
George Kittle continues to be one of the most reliable tight ends in football, and this matchup sets up perfectly for another strong outing.
The Colts’ defense appears to be trending in the wrong direction, with injuries piling up and coverage breakdowns becoming more frequent. Last week, Indianapolis surrendered 270 passing yards, and that vulnerability is exactly where Kittle can thrive.
He enters this game having recorded 60+ receiving yards in five straight contests, and with the 49ers’ offense humming, Brock Purdy should have no trouble finding his All-Pro tight end in key situations. The Dimers model projects 66 receiving yards for Kittle, putting this number squarely in range once again.
Leg 2: Christian McCaffrey 40+ Receiving Yards
Christian McCaffrey’s recent box scores don’t jump off the page as a receiver, but the context matters. Against the Browns and Titans, San Francisco leaned on others in the passing game, limiting CMC to just 21 and 14 receiving yards in those games.
This matchup presents a different challenge. The Colts have done a solid job against running backs on the ground, ranking 7th in the NFL in rushing yards allowed, which could encourage the Niners to attack them in space instead.
That opens the door for McCaffrey to reassert himself in the passing game — something he’s more than capable of doing. Dimers projects 41 receiving yards, and if Indianapolis focuses on limiting the run, CMC’s involvement as a receiver should spike.
MORE: The Dimers Sports Betting Podcast latest episodes
Leg 3: Philip Rivers 150+ Passing Yards
Philip Rivers looked respectable in his return last week against Seattle, and while this is a much tougher opponent, the game script should work in his favor.
The 49ers are unlikely to take their foot off the gas, and if San Francisco builds an early lead — as expected — Rivers will be forced to throw earlier and more often. Even in a difficult matchup, volume alone can carry this number.
Dimers projects 181 passing yards for Rivers, comfortably above the 150-yard threshold. If the Colts are playing catch-up for most of the night, Rivers should have plenty of opportunities to let it fly.
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To give you the most accurate and helpful information, this article has been reviewed and edited by Nick Slade through our fact-checking process.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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