49ers vs. Colts Preview and Prediction

49ers vs. Colts: Detailed Breakdown

Matchup Overview

• Teams: 49ers vs. Colts
• Date: Monday, December 22, 2025
• Time: 8:15 PM ET
• Venue: Lucas Oil Stadium
• NFL stats, rosters and injury reports

Current Betting Odds

• Spread: 49ers favored at -5.5
• Total (Over/Under): 45.5
• Moneyline Odds: 49ers -270, Colts +235

Dimers' Win Probabilities

• 49ers: 67%
• Colts: 33%

Dimers' predictive NFL model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Projected Final Score

Our predicted final score for this NFL matchup is 49ers 26-21 Colts.

This prediction is based on each team's average score and player stats following 10,000 game simulations.

Our Prediction: Who Wins?

After extensive simulations, our model gives the 49ers a win probability of 67%, while the Colts have a win probability of 33%.

Summary

The 49ers face off against the Colts in the NFL at Lucas Oil Stadium on Monday, December 22, 2025. On this page, you'll find our preview, analysis and data-driven projections for the game.

Our 49ers vs. Colts predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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