Oklahoma vs. South Carolina prediction: Oklahoma favored to win men's college basketball matchup [1/20/2026]

South Carolina will face Oklahoma in men's college basketball action at Colonial Life Arena on Tuesday, commencing at 7:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Oklahoma as the most likely winner of the Oklahoma vs. South Carolina game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Oklahoma vs. South Carolina prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball game between Oklahoma and South Carolina 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Oklahoma a 59% chance of defeating South Carolina. Our predicted final score has Oklahoma winning 77-74.

According to our model, Oklahoma (-1.5) has a 51% chance of covering the spread, while the over/under total of 150.5 points has a 52% chance of going over.

Oklahoma vs. South Carolina odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Oklahoma vs. South Carolina picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: