Thunder vs. Trail Blazers prediction: Why Oklahoma City is favored to win Wednesday's NBA game [11/5/2025]

The Portland Trail Blazers will take on the Oklahoma City Thunder in NBA action at Moda Center on Wednesday, commencing at 10:00PM ET.

Based on updated simulations and today’s injury news, Dimers' advanced NBA model predicts the Thunder as the most likely winner of the Thunder vs. Trail Blazers game.

This prediction follows the latest NBA Injury Report, which suggests the Trail Blazers lineup will feature players like Deni Avdija, Shaedon Sharpe and Jerami Grant, while the Thunder will rely on Shai Gilgeous-Alexander, Aaron Wiggins and Ajay Mitchell.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Thunder vs. Blazers prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the result of Wednesday's NBA game between the Thunder and Trail Blazers 10,000 times as part of our NBA predictions coverage.

Our independent predictive model currently gives the Thunder a 63% chance of defeating the Trail Blazers. Our predicted final score has the Thunder winning 117-113.

According to our model, the Thunder (-3.5) have a 51% chance of covering the spread, while the over/under total of 231.5 points has a 51% chance of staying under.

Thunder vs. Trail Blazers odds

We have researched the best NBA odds in America for this game, which are listed here:

Bet Type	Thunder	Trail Blazers
Spread	-3.5 (-110)	+3.5 (-105)
Moneyline	-164	+145
Total	o231.5 (-106)	u231.5 (-108)

All odds are correct at the time of publication and are subject to change.

Thunder vs. Trail Blazers picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Thunder -3.5	-110
Moneyline	Thunder	-164
Total	Under 231.5	-108

According to our best NBA bets for Wednesday, the top play to make on this game is Thunder to win.

Thunder vs. Trail Blazers player props

Betting on Thunder vs. Trail Blazers NBA player props? We have crunched the numbers to project how each team's leading players will perform at Moda Center.

Shai Gilgeous-Alexander is expected to lead the Thunder with 30 points, 5 rebounds and 6 assists, while Deni Avdija is projected to have 20 points, 8 rebounds and 4 assists for the Trail Blazers.

Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.

Thunder prediction

Our model's projected player stats for the Thunder are:

Player	PTS	REB	AST	3PM
Shai Gilgeous-Alexander	30	5	6	2
Aaron Wiggins	15	5	2	2
Ajay Mitchell	15	4	3	2
Isaiah Joe	14	4	2	3
Isaiah Hartenstein	11	10	4	0

Trail Blazers prediction

Projected points, rebounds, assists and three-pointers made for the Trail Blazers:

Player	PTS	REB	AST	3PM
Deni Avdija	20	8	4	2
Shaedon Sharpe	17	4	2	2
Jerami Grant	15	3	2	2
Jrue Holiday	13	5	5	2
Toumani Camara	13	5	3	2

Thunder vs. Blazers game-day updates and essential details

Wednesday's action between the Trail Blazers and Thunder at Moda Center is scheduled to commence at 10:00PM ET.

• Who: Oklahoma City Thunder vs. Portland Trail Blazers
• Date: Wednesday, November 5, 2025
• Time: 10:00PM ET/7:00PM PT
• Venue: Moda Center

Conclusion

We predict the Thunder, with a 63% win probability, will likely beat the Trail Blazers on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Thunder vs. Trail Blazers insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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