Ohio State vs. USC Prediction: Ohio State Predicted to Win College Basketball Matchup [2/26/2025]

USC and Ohio State will lock horns in college basketball action at Galen Center on Wednesday, starting at 10:30PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model (see Dimers Pro for full access) predicts Ohio State as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has simulated the outcome of Wednesday's Ohio State-USC game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate Ohio State's chance of winning at 53%, with USC at 47%."

For further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Ohio State vs. USC predictions page.

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Ohio State vs. USC Prediction: Who Will Win, Cover the Spread?

Using powerful machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball game between Ohio State and USC 10,000 times as part of our college basketball predictions coverage.

Our leading predictive model gives Ohio State a 53% chance of beating USC. Our predicted score is Ohio State 74-74 USC.

According to our model, USC (+1.5) has a 55% chance of covering the spread, while the 149.5-point over/under has a 52% chance of staying under.

While there is no way for a College Basketball game to end in a tie, our prediction of 74-74 is based on each team's average score in the above-mentioned simulations of Ohio State vs. USC.

Ohio State vs. USC Odds

We have sourced the best College Basketball odds in America for this game, which are listed here:

Bet Type	Ohio State	USC
Spread	-1.5 (-105)	+1.5 (-114)
Moneyline	-120	+105
Total	o149.5 (-108)	u149.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Ohio State vs. USC Picks and Best Bets

Our model's biggest edge in today's Ohio State vs. USC matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Ohio State vs. USC Game-Day Updates and Essential Details

Wednesday's college basketball matchup between USC and Ohio State at Galen Center is scheduled to begin at 10:30PM ET.

• Who: Ohio State vs. USC
• Date: Wednesday, February 26, 2025
• Time: 10:30PM ET/7:30PM PT
• Venue: Galen Center

Dimers.com's comprehensive preview of Wednesday's Ohio State vs. USC matchup includes our prediction, picks and the latest betting odds.

Before making any Ohio State vs. USC picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Ohio State, with a 53% win probability, will likely beat USC on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Ohio State vs. USC insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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