...
...
Read Article
- More Betting
Notre Dame vs. Louisville prediction: Louisville favored to win men's college basketball matchup [2/4/2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Notre Dame vs Louisville predictions for college basketball Wednesday.
Louisville and Notre Dame are scheduled to meet in men's college basketball action at KFC Yum! Center on Wednesday, with tipoff at 7:00 PM ET.
Based on the latest simulations, Dimers' proven college basketball model projects Louisville as the most likely winner of the Notre Dame vs. Louisville game.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Notre Dame vs. Louisville prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball game between Notre Dame and Louisville 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model gives Louisville a 96% chance of beating Notre Dame. Our predicted final score has Louisville winning 87-67.
According to our model, Louisville (-18.5) has a 53% chance of covering the spread, while the 155.5-point over/under has an equal 50-50 chance of hitting.
Notre Dame vs. Louisville odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Notre Dame | Louisville |
|---|---|---|
| Spread | +18.5 (-105) | -18.5 (-105) |
| Moneyline | +1280 | -2400 |
| Total | o155.5 (-110) | u155.5 (-105) |
All odds are correct at the time of publication and are subject to change.
Notre Dame vs. Louisville picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville -18.5 | -105 |
| Moneyline | Louisville | -2400 |
| Total | Under 155.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Louisville -18.5 at the spread.
Notre Dame vs. Louisville game-day updates and essential details
Wednesday's men's college basketball game between Louisville and Notre Dame at KFC Yum! Center is scheduled to begin at 7:00 PM ET.
- Who: Notre Dame vs. Louisville
- Date: Wednesday, February 4, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: KFC Yum! Center
Conclusion
We predict Louisville, with a 96% win probability, will likely beat Notre Dame on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Notre Dame vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure