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Northwestern vs. USC prediction: USC favored to win men's college basketball matchup [1/21/2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Northwestern vs USC predictions for college basketball Wednesday.
USC and Northwestern will lock horns in men's college basketball action at Galen Center on Wednesday, with tipoff at 11:00 PM ET.
Based on updated simulation results, Dimers' proven college basketball model predicts USC as the most likely winner of the Northwestern vs. USC game.
This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.
Northwestern vs. USC prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Northwestern and USC 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives USC a 76% chance of beating Northwestern. Our predicted final score has USC winning 80-72.
According to our model, USC (-6.5) has a 57% chance of covering the spread, while the over/under total of 149.5 points has a 54% chance of going over.
Northwestern vs. USC odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Northwestern | USC |
|---|---|---|
| Spread | +6.5 (-105) | -6.5 (-110) |
| Moneyline | +245 | -298 |
| Total | o149.5 (-105) | u149.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Northwestern vs. USC picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | USC -6.5 | -110 |
| Moneyline | USC | -298 |
| Total | Over 149.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is USC -6.5 at the spread.
Northwestern vs. USC game-day updates and essential details
Wednesday's men's college basketball game between USC and Northwestern at Galen Center is scheduled to start at 11:00 PM ET.
- Who: Northwestern vs. USC
- Date: Wednesday, January 21, 2026
- Time: 11:00 PM ET/8:00PM PT
- Venue: Galen Center
Conclusion
We predict USC, with a 76% win probability, will likely beat Northwestern on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Northwestern vs. USC insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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