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Northwestern vs. South Carolina prediction: Northwestern favored to win men's college basketball matchup [11/23/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Northwestern vs South Carolina predictions for college basketball Sunday.
South Carolina will face the favored Northwestern in men's college basketball action at Colonial Hall on Sunday, beginning at 5:00PM ET.
Based on updated simulation results, Dimers' proven college basketball model predicts Northwestern as the most likely winner of the Northwestern vs. South Carolina game.
This article offers a closer look at Sunday's matchup, including an expanded look at the predicted score, best bets and picks.
Northwestern vs. South Carolina prediction: Who will win and cover?
Using innovative machine learning and statistical analysis, we have simulated the result of Sunday's NCAA basketball game between Northwestern and South Carolina 10,000 times as part of our men's college basketball predictions coverage.
Our leading predictive model gives Northwestern a 72% chance of beating South Carolina. Our predicted final score has Northwestern winning 76-70.
According to our model, South Carolina (+5.5) has a 55% chance of covering the spread, while the 146.5-point over/under has a 53% chance of going over.
Northwestern vs. South Carolina odds
We have researched the best Men's College Basketball odds in America for this game, which are listed here:
| Bet Type | Northwestern | South Carolina |
|---|---|---|
| Spread | -5.5 (-112) | +5.5 (-105) |
| Moneyline | -250 | +225 |
| Total | o146.5 (-105) | u146.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Northwestern vs. South Carolina picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | South Carolina +5.5 | -105 |
| Moneyline | Northwestern | -250 |
| Total | Over 146.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is South Carolina +5.5 at the spread.
Northwestern vs. South Carolina game-day updates and essential details
Sunday's men's college basketball game between South Carolina and Northwestern at Colonial Hall is scheduled to begin at 5:00PM ET.
- Who: Northwestern vs. South Carolina
- Date: Sunday, November 23, 2025
- Time: 5:00PM ET/2:00PM PT
- Venue: Colonial Hall
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Conclusion
We predict Northwestern, with a 72% win probability, will likely beat South Carolina on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Northwestern vs. South Carolina insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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