Northern Iowa vs. Southern Illinois prediction: Northern Iowa favored to win men's college basketball matchup [1/28/2026]

Men's college basketball action continues on Wednesday at 7:00 PM ET as Northern Iowa squares off with Southern Illinois in men's college basketball action at Banterra Center.

Based on updated simulation results, Dimers' advanced college basketball model gives Northern Iowa a slight edge with a 54% win probability over Southern Illinois.

This article offers a closer look at Wednesday's Northern Iowa vs. Southern Illinois matchup, including an expanded look at the predicted score, best bets and picks.

Northern Iowa vs. Southern Illinois prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball game between Northern Iowa and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Northern Iowa a 54% chance of defeating Southern Illinois. Our predicted final score has Northern Iowa winning 68-67.

According to our model, Southern Illinois (+1.5) has a 52% chance of covering the spread, while the 130.5-point over/under has a 56% chance of going over.

Northern Iowa vs. Southern Illinois odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Northern Iowa vs. Southern Illinois picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Over 130.5 total points.

Northern Iowa vs. Southern Illinois game-day updates and essential details

Wednesday's men's college basketball action between Southern Illinois and Northern Iowa at Banterra Center is scheduled to begin at 7:00 PM ET.

• Who: Northern Iowa vs. Southern Illinois
• Date: Wednesday, January 28, 2026
• Time: 7:00 PM ET/4:00PM PT
• Venue: Banterra Center

Conclusion

We predict Northern Iowa, with a 54% win probability, will likely beat Southern Illinois on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Northern Iowa vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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