NFL picks straight up: Divisional Round, 2026

At Dimers, our Divisional Round NFL picks are grounded in data-driven insight, with straight-up picks for each of the games informed by our latest NFL predictions.

Secure an advantage in your NFL pick 'em contests via our data-driven NFL Divisional Round picks straight up, powered by thousands of game simulations.

Divisional Round starts with the Buffalo Bills facing the Denver Broncos on Saturday and ends with the Los Angeles Rams taking on the Chicago Bears on Sunday.

NFL picks this week straight up: Divisional Round 2026

Here are our Divisional Round NFL picks, highlighting how likely each team is to win their game this week.

Buffalo Bills vs. Denver Broncos

The Bills kick off this week's playoffs slate against the Broncos at Empower Field at Mile High on Saturday. According to our model, the Broncos have a 56% chance of winning, while the Bills have a 44% chance.

For the weekend's opening game, our model highlights NFL player props with James Cook (RB) as the most likely player from the Bills to score the first TD at 12.0%, while RJ Harvey (RB) is the top candidate from the Broncos at 11.8%.

The Buffalo Bills vs. Denver Broncos game at Empower Field at Mile High is scheduled for Saturday, January 17 at 4:30pm. All times mentioned in this article are in Eastern Standard Time (EST).

San Francisco 49ers vs. Seattle Seahawks

For this week's game between the 49ers and the Seahawks, Seattle is more likely to win. Our prediction model gives the Seahawks a 75% chance of winning. On the other hand, there is a 25% chance that the 49ers will pull off an upset win.

The San Francisco 49ers vs. Seattle Seahawks matchup at Lumen Field will take place on Saturday, January 17 at 8:00pm.

As the playoffs continue, track the top teams with Dimers' updated NFL futures, highlighting top Super Bowl contenders.

Houston Texans vs. New England Patriots

We are picking the Patriots to win their game against the Texans this week, with our famous NFL model projecting a 62% win probability for the home team. The Texans have a 38% chance of winning at Gillette Stadium.

For betting purposes, the Patriots are listed as -3 favorites, with the Texans' moneyline at +145.

The Houston Texans vs. New England Patriots game at Gillette Stadium is slated for Sunday, January 18 at 3:00pm.

Los Angeles Rams vs. Chicago Bears

According to our predictive analytics model, the Rams are the team to beat in this game, with their win probability at 61%. The Bears, on the other hand, have a 39% chance of winning.

The Los Angeles Rams vs. Chicago Bears game at Soldier Field is set for Sunday, January 18 at 6:30pm.

Full list of NFL Divisional Round picks straight up

• Broncos (56% win probability)
• Seahawks (75%)
• Patriots (62%)
• Rams (61%)

For more insights into this week's NFL predictions, check out the latest from the Dimers Sports Betting Podcast:

NFL straight up picks and predictions for Divisional Round

The NFL Divisional Round predictions straight up in this article are accurate at the time of publication but may change.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.