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Pelicans vs. Grizzlies prediction: Why Memphis is favored to win Wednesday's NBA matchup [10/22/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get New Orleans Pelicans vs Memphis Grizzlies predictions for NBA Wednesday.
The Memphis Grizzlies and New Orleans Pelicans will lock horns in NBA action at FedExForum on Wednesday, with tipoff at 8:00PM ET.
Based on the latest simulations and today’s injury news, Dimers' advanced NBA model predicts the Grizzlies as the most likely winner of today's game.
"Our team has simulated the outcome of Wednesday's Pelicans-Grizzlies game 10,000 times," said Damien Souness from Dimers.
"With the latest updates and numerous other variables, we estimate the Grizzlies' chance of winning at 63%, with the Pelicans at 37%."
This prediction follows the latest NBA Injury Report, which suggests the Grizzlies lineup will feature stars like Ja Morant, Jaren Jackson and Santi Aldama, while the Pelicans will be led by Zion Williamson, Trey Murphy and Jordan Poole.
For expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks, visit our interactive Pelicans vs. Grizzlies predictions page.
Pelicans vs. Grizzlies prediction: Who will win, cover the spread?
Using trusted machine learning and data analysis, we have simulated the result of Wednesday's NBA matchup between the Pelicans and Grizzlies 10,000 times as part of our NBA predictions coverage.
Our leading predictive model currently gives the Grizzlies a 63% chance of defeating the Pelicans. Our predicted final score has the Grizzlies winning 119-115.
According to our model, the Grizzlies (-4.5) have a 51% chance of covering the spread, while the over/under total of 236.5 points has a 51% chance of staying under.
Pelicans vs. Grizzlies odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | Pelicans | Grizzlies |
|---|---|---|
| Spread | +4.5 (-115) | -4.5 (-105) |
| Moneyline | +148 | -175 |
| Total | o236.5 (-106) | u236.5 (-108) |
All odds are correct at the time of publication and are subject to change.
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Pelicans vs. Grizzlies picks and best bets
Our model's biggest edge in today's Pelicans vs. Grizzlies matchup is on the moneyline.
Our expert predictions, matched against the current odds, reveal the best NBA picks and NBA best bets for every game throughout the season.
Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.
Pelicans vs. Grizzlies player props
NBA prop bets are an enjoyable way to wager on Wednesday's Pelicans vs. Grizzlies game without necessarily betting on the outcome. We have crunched the numbers to project how each team's leading players will perform at FedExForum.
Zion Williamson is expected to lead the Pelicans in scoring, while Ja Morant is projected to be the top scorer for the Grizzlies.
Dimers Pro users can access a full range of player props and projected box scores, including points, assists, rebounds and more, for every NBA game this season.
Pelicans vs. Grizzlies game-day updates and essential details
Wednesday's matchup between the Grizzlies and Pelicans at FedExForum is scheduled to start at 8:00PM ET.
- Who: New Orleans Pelicans vs. Memphis Grizzlies
- Date: Wednesday, October 22, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: FedExForum
Dimers' full preview of Wednesday's Pelicans vs. Grizzlies matchup includes our prediction, picks and the latest betting odds.
Before making any Pelicans vs. Grizzlies picks, be sure to check out the latest NBA predictions and betting advice from Dimers Pro.
Conclusion
We predict the Grizzlies, with a 63% win probability, will likely beat the Pelicans on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Pelicans vs. Grizzlies insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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