MLS betting tips: Wednesday's picks include Salt Lake vs. Portland play [10/22/2025]

Today’s MLS betting tips for October 22, 2025 are here, with Wednesday’s MLS best bets backed by tens of thousands of data simulations analyzing the latest odds and matchups.

These MLS best bets include matchups like the Salt Lake vs. Portland game at 10:30PM ET, with this article updated throughout the day to feature the highest-probability plays based on thousands of data-driven simulations from our predictive analytics model.

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Pro members get unlimited access to everything Dimers has to offer on Wednesday, October 22, 2025, including our full set of picks and best bets for today and the week ahead.

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List of MLS betting tips tonight [10/22, updated 8:02PM ET]

After digging deep into the numbers and running thousands of simulations, our famous predictive analytics model has figured out the best soccer bets for Wednesday, October 22, 2025.

Portland ML (+115)

• Probability: 49.3%
• Edge: 2.7%
• Matchup: Salt Lake vs. Portland (10:30PM ET, Wednesday)

Our model has pinpointed a high-probability MLS betting opportunity tonight, which comes in the Salt Lake vs. Portland matchup. We recommend a bet on the Portland ML at +115 odds, with our analysis showing a 49.3% chance of hitting and a compelling edge of 2.7%.

Salt Lake vs. Portland under 2.5 goals (+136)

• Probability: 46.6%
• Edge: 4.2%
• Matchup: Salt Lake vs. Portland (10:30PM ET, Wednesday)

Our model has found another strong MLS bet for Wednesday's soccer action, again in the game between Salt Lake and Portland. We suggest placing an over/under wager on under 2.5 goals at +136 odds, with a 46.6% probability delivering a 4.2% edge.

MLS best bets: Wednesday, 10/22/2025

As of 8:02PM ET, here are our top two MLS bets by probability recommended by our model:

Matchup	Bet	Odds	Probability	Edge
Salt Lake vs. Portland	Portland ML	+115 @ BetMGM	49.3%	2.7%
Salt Lake vs. Portland	Under 2.5 Goals	+136 @ FanDuel	46.6%	4.2%

Dimers Pro unlocks instant access to the most valuable bets across all sports, powered by our advanced predictive model.

Today, Dimers Pro subscribers have access to two MLS picks—with access to all of these being what makes a difference over time.

Join Dimers Pro now to access these picks, as well as a comprehensive range of props, trends and parlays for October 22, 2025.

List of upcoming MLS games to bet on [10/22/2025]

• Orlando vs. Chicago (8:30PM ET, Wednesday)
• Salt Lake vs. Portland (10:30PM ET, Wednesday)

More about MLS

The bets on this page form part of our MLS best bets series.

For more MLS betting content, we have MLS betting news and the latest MLS Cup odds and predictions.

Conclusion

Our MLS best bets are locked and loaded for October 22, 2025, featuring plays such as Portland ML and under 2.5 goals also in the Salt Lake vs. Portland matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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