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Read Article MLB picks today: Wednesday's MLB best bets include White Sox vs. Diamondbacks play [4/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get MLB picks today and best bets for Wednesday, April 22, 2026.
Today’s MLB picks for April 22, 2026 are here, with White Sox vs. Diamondbacks and Brewers vs. Tigers among the top plays identified by our model across Wednesday’s MLB schedule.
Dimers’ predictive analytics engine runs 24/7, scanning the latest baseball odds to unearth real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.
List of MLB best bets tonight [4/22, updated 9:32PM ET]
Below, you’ll find today’s best baseball bets, ranked by edge for Wednesday, April 22, 2026.
White Sox vs. Diamondbacks over 9 runs (-102)
- Edge: 4.6%
- Probability: 55.1%
- Matchup: White Sox vs. Diamondbacks (9:40PM ET, Wednesday)
Our model has identified value on over 9 runs in White Sox vs. Diamondbacks at -102 odds. A 55.1% probability produces an edge of 4.6%, making this the strongest play for today's MLB slate.
Brewers vs. Tigers over 7 runs (+100)
- Edge: 3.4%
- Probability: 53.4%
- Matchup: Brewers vs. Tigers (1:10PM ET, Thursday)
Brewers vs. Tigers over 7 runs carries a 3.4% edge and a probability of 53.4% at +100 odds, according to our model.
Yankees vs. Red Sox over 8.5 runs (-105)
- Edge: 3.2%
- Probability: 54.4%
- Matchup: Yankees vs. Red Sox (6:10PM ET, Thursday)
Yankees vs. Red Sox over 8.5 runs at -105 odds shows a 3.2% edge, supported by a 54.4% probability in simulations.
Dodgers vs. Giants over 7 runs (-122)
- Edge: 2.6%
- Probability: 57.5%
- Matchup: Dodgers vs. Giants (3:45PM ET, Thursday)
A 2.6% edge and 57.5% probability make Dodgers vs. Giants over 7 runs at a value play in the Dodgers vs. Giants matchup, per our model.
Braves vs. Nationals over 9 runs (-105)
- Edge: 2.4%
- Probability: 53.6%
- Matchup: Braves vs. Nationals (1:05PM ET, Thursday)
Braves vs. Nationals over 9 runs at -105 odds presents a 2.4% edge, with simulations resulting in a probability of 53.6%.
MLB best bets summary: Wednesday, 4/22/2026
As of 9:32PM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| White Sox vs. Diamondbacks | Over 9 Runs | -102 @ DraftKings | 4.6% | 55.1% |
| Brewers vs. Tigers | Over 7 Runs | +100 @ BetMGM | 3.4% | 53.4% |
| Yankees vs. Red Sox | Over 8.5 Runs | -105 @ FanDuel | 3.2% | 54.4% |
| Dodgers vs. Giants | Over 7 Runs | -122 @ FanDuel | 2.6% | 57.5% |
| Braves vs. Nationals | Over 9 Runs | -105 @ FanDuel | 2.4% | 53.6% |
List of upcoming MLB games to bet on [4/22/2026]
- White Sox vs. D-Backs (9:40PM ET, Wednesday)
- Dodgers vs. Giants (9:45PM ET, Wednesday)
- Braves vs. Nationals (1:05PM ET, Thursday)
- Brewers vs. Tigers (1:10PM ET, Thursday)
- Phillies vs. Cubs (2:20PM ET, Thursday)
- Padres vs. Rockies (3:10PM ET, Thursday)
- White Sox vs. D-Backs (3:40PM ET, Thursday)
- Dodgers vs. Giants (3:45PM ET, Thursday)
- Yankees vs. Red Sox (6:10PM ET, Thursday)
- Twins vs. Mets (7:10PM ET, Thursday)
- Pirates vs. Rangers (8:05PM ET, Thursday)
Conclusion
Our MLB best bets are locked and loaded for April 22, 2026, featuring plays such as over 9 runs in the White Sox vs. Diamondbacks matchup and over 7 runs in the Brewers vs. Tigers matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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