White Sox vs. D-Backs Prediction, Picks and Odds

Our detailed prediction and analysis for the White Sox vs. D-Backs MLB game on April 22, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
FINAL
MLB
Add this game to My Favorites
FINAL
Add this game to My Favorites
MLB sport icon
MLB
White Sox
Anthony Kay 1-0, 2.60 ERA
7
11
Chase Field
D-Backs
Eduardo Rodriguez 1-0, 1.96 ERA
Chase Field
1 2 3 4 5 6 7 8 9 RHE
White Sox
2 0 1 1 0 1 2 0 0 7 11 0
D-Backs
0 4 2 2 0 2 1 0 X 11 16 0
Live Probabilities
Win %
  • White Sox
    0%
  • D-Backs
    100%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
Colson Montgomery flies out to deep left field to Lourdes Gurriel.
Quick Box Score
White Sox Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 C. Meidroth 2B5110000.2000.400
2 M. Vargas 3B4321111.5001.850
3 M. Murakami 1B5132101.6001.800
4 E. Pereira DH4020010.5001.100
5 E. Quero C3001021.0000.400
6 C. Montgomery SS5112102.2001.000
7 S. Antonacci LF2010000.5001.000
8 T. Peters CF2110001.5002.000
9 A. Benintendi RF2001001.0000.000
D-Backs Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 K. Marte 2B5120001.4001.000
2 C. Carroll RF4231010.7502.050
3 G. Perdomo SS4131011.7502.550
4 L. Gurriel LF5000000.0000.000
5 J. Fernandez DH3220020.6671.467
6 N. Arenado 3B43431101.0002.750
7 I. Vargas 1B5225201.4002.000
8 J. McCann C5000002.0000.000
9 J. Barrosa CF3000010.0000.250

White Sox vs. D-Backs: Detailed Breakdown

Matchup Overview

  • Teams: White Sox vs. D-Backs
  • Date: Wednesday, April 22, 2026
  • Time: 9:40 PM ET
  • Venue: Chase Field

Current Betting Odds

  • Spread: D-Backs favored at -1.5
  • Total (Over/Under): 9.5
  • Moneyline Odds: White Sox 41¢, D-Backs 59¢

Dimers' Win Probabilities

  • White Sox: 40%
  • D-Backs: 60%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the White Sox a win probability of 40%, while the D-Backs have a win probability of 60%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the D-Backs are more likely to beat the White Sox in the MLB game at Chase Field on Thursday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our White Sox vs. D-Backs predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may receive a referral fee.

For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.