Jun 22, 2026
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Read Article MLB picks today: Monday's MLB best bets include Braves vs. Padres play [6/22/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get MLB picks today and best bets for Monday, June 22, 2026.
Today’s MLB picks for June 22, 2026 are here, with Braves vs. Padres and Astros vs. Blue Jays among the top plays identified by our model across Monday’s MLB schedule.
Dimers’ predictive analytics engine runs 24/7, going over the latest baseball odds to find top betting edges. The result? Data-backed plays that help Dimers Pro members make smarter decisions.
List of MLB best bets today [6/22, updated 12:06AM ET]
Below, you’ll find today’s top 10 baseball bets, ranked by edge for Monday, June 22, 2026.
Braves vs. Padres Over 4.5 runs (+100)
- Edge: 12.0%
- Probability: 62%
- Matchup: Braves vs. Padres (10:10PM ET)
Our model has identified value on Over 4.5 runs in Braves vs. Padres at +100 odds. A 62% probability produces an edge of 12.0%, making this the strongest play for today's MLB slate.
Astros vs. Blue Jays Over 7.5 runs (+115)
- Edge: 5.7%
- Probability: 52.2%
- Matchup: Astros vs. Blue Jays (7:07PM ET)
Astros vs. Blue Jays over 7.5 runs carries a 5.7% edge and a probability of 52.2% at +115 odds, according to our model.
Dodgers vs. Twins Over 9.5 runs (+111)
- Edge: 5.2%
- Probability: 52.7%
- Matchup: Dodgers vs. Twins (7:40PM ET)
Dodgers vs. Twins Over 9.5 runs at +111 odds shows a 5.2% edge, supported by a 52.7% probability in simulations.
Royals vs. Rays over 7.5 runs (+115)
- Edge: 5.2%
- Probability: 51.7%
- Matchup: Royals vs. Rays (6:40PM ET)
A 5.2% edge and 51.7% probability make Royals vs. Rays over 7.5 runs a value play in the Royals vs. Rays matchup, per our model.
Orioles vs. Angels Over 8.5 runs (-115)
- Edge: 4.9%
- Probability: 58.4%
- Matchup: Orioles vs. Angels (9:38PM ET)
Orioles vs. Angels Over 8.5 runs at -115 odds presents a 4.9% edge, with simulations resulting in a probability of 58.4%.
Tigers ML (+120)
- Edge: 4.8%
- Probability: 50.3%
- Matchup: Yankees vs. Tigers (6:10PM ET)
Our model finds value on Tigers to win at +120 odds, supported by an edge of 4.8%.
Tigers +1.5 (-141)
- Edge: 4.3%
- Probability: 62.8%
- Matchup: Yankees vs. Tigers (6:10PM ET)
Our model has uncovered value on Tigers +1.5 at -141 odds. A 62.8% probability produces a 4.3% edge, making this a strong play for today's MLB action.
Royals ML (+167)
- Edge: 4.2%
- Probability: 41.7%
- Matchup: Royals vs. Rays (6:40PM ET)
A 4.2% edge on a 41.7% probability makes Royals to win at +167 odds a solid value play in today's Royals vs. Rays matchup.
Mets ML (+111)
- Edge: 3.9%
- Probability: 51.4%
- Matchup: Cubs vs. Mets (7:10PM ET)
Our model projects value on Mets to win at +111 odds. A 51.4% probability produces a 3.9% edge, making Mets the favorable ML play in today's matchup.
Diamondbacks vs. Cardinals Over 8.5 runs (-102)
- Edge: 3.6%
- Probability: 54.1%
- Matchup: Diamondbacks vs. Cardinals (7:45PM ET)
Rounding out our top 10 bets, Diamondbacks vs. Cardinals Over 8.5 runs at -102 odds shows a 54.1% probability and a 3.6% edge.
MLB best bets summary: Monday, 6/22/2026
As of 12:06AM ET, here are our top MLB bets by edge recommended by our model:
| Matchup | Bet | Odds | Edge | Probability |
|---|---|---|---|---|
| Braves vs. Padres | Over 4.5 runs | +100 @ Polymarket | 12.0% | 62% |
| Astros vs. Blue Jays | Over 7.5 runs | +115 @ Kalshi | 5.7% | 52.2% |
| Dodgers vs. Twins | Over 9.5 Runs | +111 @ Kalshi | 5.2% | 52.7% |
| Royals vs. Rays | over 7.5 runs | +115 @ Kalshi | 5.2% | 51.7% |
| Orioles vs. Angels | Over 8.5 Runs | -115 @ Kalshi | 4.9% | 58.4% |
| Yankees vs. Tigers | Tigers ML | +120 @ Kalshi | 4.8% | 50.3% |
| Yankees vs. Tigers | Tigers +1.5 | -141 @ Kalshi | 4.3% | 62.8% |
| Royals vs. Rays | Royals ML | +167 @ Polymarket | 4.2% | 41.7% |
| Cubs vs. Mets | Mets ML | +111 @ Polymarket | 3.9% | 51.4% |
| Diamondbacks vs. Cardinals | Over 8.5 Runs | -102 @ Polymarket | 3.6% | 54.1% |
List of upcoming MLB games to bet on [6/22/2026]
- Yankees vs. Tigers (6:10PM ET, Monday)
- Royals vs. Rays (6:40PM ET, Monday)
- Rangers vs. Marlins (6:40PM ET, Monday)
- Astros vs. Blue Jays (7:07PM ET, Monday)
- Brewers vs. Reds (7:10PM ET, Monday)
- Cubs vs. Mets (7:10PM ET, Monday)
- Dodgers vs. Twins (7:40PM ET, Monday)
- Guardians vs. White Sox (7:40PM ET, Monday)
- D-Backs vs. Cardinals (7:45PM ET, Monday)
- Red Sox vs. Rockies (8:40PM ET, Monday)
- Orioles vs. Angels (9:38PM ET, Monday)
- Braves vs. Padres (10:10PM ET, Monday)
Conclusion
Our MLB best bets are locked and loaded for June 22, 2026, featuring plays such as Over 4.5 runs in the Braves vs. Padres matchup and Over 7.5 runs in the Astros vs. Blue Jays matchup. Powered by advanced simulations, these picks are here to boost your betting game.
Our predictions are grounded in current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.
All odds and probabilities in this article are correct and accurate at the time of publication.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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