Mississippi Valley State vs. Southern University prediction: Southern University favored to win men's college basketball matchup [1/28/2026]

Southern University will square off with Mississippi Valley State in men's college basketball action at F.G. Clark Activity Center on Wednesday, starting at 2:00 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model projects Southern University as the most likely winner of the Mississippi Valley State vs. Southern University game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Mississippi Valley State vs. Southern University prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's NCAA basketball game between Mississippi Valley State and Southern University 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Southern University a 97% chance of defeating Mississippi Valley State. Our predicted final score has Southern University winning 83-62.

According to our model, Southern University (-20.5) has a 51% chance of covering the spread, while the over/under total of 142.5 points has a 54% chance of going over.

Mississippi Valley State vs. Southern University odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Mississippi Valley State vs. Southern University picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best men's college basketball bets, the top play to make on this game is Over 142.5 total points.

Mississippi Valley State vs. Southern University game-day updates and essential details

Wednesday's men's college basketball action between Southern University and Mississippi Valley State at F.G. Clark Activity Center is scheduled to commence at 2:00 PM ET.

• Who: Mississippi Valley State vs. Southern University
• Date: Wednesday, January 28, 2026
• Time: 2:00 PM ET/11:00AM PT
• Venue: F.G. Clark Activity Center

Conclusion

We predict Southern University, with a 97% win probability, will likely beat Mississippi Valley State on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi Valley State vs. Southern University insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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