Mississippi State vs. New Mexico prediction: Mississippi State favored to win men's college basketball matchup [11/21/2025]

New Mexico and Mississippi State are scheduled to meet in men's college basketball action at T-Mobile Center on Friday, with tipoff at 7:00PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Mississippi State as the most likely winner of the Mississippi State vs. New Mexico game.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Mississippi State vs. New Mexico prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Friday's NCAA basketball matchup between Mississippi State and New Mexico 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Mississippi State a 66% chance of defeating New Mexico. Our predicted final score has Mississippi State winning 77-73.

According to our model, New Mexico (+6.5) has a 61% chance of covering the spread, while the 150.5-point over/under has a 54% chance of staying under.

Mississippi State vs. New Mexico odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Mississippi State vs. New Mexico picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is New Mexico +6.5 at the spread.

Mississippi State vs. New Mexico game-day updates and essential details

Friday's men's college basketball game between New Mexico and Mississippi State at T-Mobile Center is scheduled to start at 7:00PM ET.

• Who: Mississippi State vs. New Mexico
• Date: Friday, November 21, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: T-Mobile Center

Conclusion

We predict Mississippi State, with a 66% win probability, will likely beat New Mexico on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi State vs. New Mexico insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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