Mississippi State vs. Iowa State prediction: Why Iowa State is favored to win men's college basketball matchup [11/10/2025]

Iowa State and Mississippi State are scheduled to meet in men's college basketball action at Sanford Pentagon on Monday, with tipoff at 8:00PM ET.

Based on updated simulation results, Dimers' advanced college basketball model predicts Iowa State as the most likely winner of the Mississippi State vs. Iowa State game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Mississippi State vs. Iowa State prediction: Who will win, cover the spread?

Using innovative machine learning and data, we have simulated the outcome of Monday's NCAA basketball game between Mississippi State and Iowa State 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Iowa State a 70% chance of beating Mississippi State. Our predicted final score has Iowa State winning 77-71.

According to our model, the bookmakers have got it right, and Mississippi State and Iowa State each have a 50% chance of covering the spread, while the 150.5-point over/under has a 52% chance of staying under.

Mississippi State vs. Iowa State odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Mississippi State vs. Iowa State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Mississippi State +5.5 at the spread.

Mississippi State vs. Iowa State game-day updates and essential details

Monday's men's college basketball action between Iowa State and Mississippi State at Sanford Pentagon is scheduled to begin at 8:00PM ET.

• Who: Mississippi State vs. Iowa State
• Date: Monday, November 10, 2025
• Time: 8:00PM ET/5:00PM PT
• Venue: Sanford Pentagon

Conclusion

We predict Iowa State, with a 70% win probability, will likely beat Mississippi State on Monday.

AI and automation have enhanced this article to quickly deliver accurate Mississippi State vs. Iowa State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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