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Vikings vs. Giants prediction: Minnesota favored to win in NFL Week 16 [2025]

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Written by Mac Douglass

Get Minnesota Vikings vs New York Giants predictions for NFL Sunday.

Minnesota Vikings-New York Giants Predictions and Game Preview.
Minnesota Vikings vs. New York Giants NFL prediction for Sunday, December 21, 2025.

NFL Week 16 action continues on Sunday at 1:00 PM ET as the Minnesota Vikings take on the New York Giants at MetLife Stadium.

Based on the latest simulations, Dimers' proven NFL model predicts the Vikings as the most likely winner of the Vikings vs. Giants game.

This article offers an expanded analysis of this week's matchup, including projected touchdown scorers, best bets and player prop picks.

Vikings vs. Giants prediction: Who will win and cover?

Since our Vikings-Giants predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Vikings and Giants 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Vikings a 56% chance of defeating the Giants in Week 16 of the NFL season. Our predicted final score has the Vikings winning 22-21.

According to our model, the Giants (+2.5) have a 58% chance of covering the spread, while the over/under total of 43.5 points has an equal 50-50 chance of hitting.

 

To see win probabilities for every matchup this week, check out our expert NFL Week 16 straight up picks.

Vikings vs. Giants odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type Vikings Giants
Spread -2.5 (-118) +2.5 (-102)
Moneyline -144 +125
Total o43.5 (-105) u43.5 (-115)

All odds are correct at the time of publication and are subject to change.

Vikings vs. Giants picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Mac Douglass
Senior Editor

Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.

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