Men's college basketball picks today: Wednesday's best bets include two spread plays [11/5/2025]

Today’s men's college basketball picks for November 5, 2025 are here, with USC Upstate vs. Fresno State among the top plays identified by our model across Wednesday’s men's college basketball slate.

Dimers’ predictive analytics engine runs 24/7, scanning the latest men's college basketball odds to uncover genuine betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of NCAAM picks tonight [11/5, updated 8:33PM ET]

Below, you’ll find today’s best men's college basketball bets, ranked by edge for Wednesday, November 5, 2025.

USC Upstate vs. Fresno State under 164.5 points (-105)

• Edge: 4.9%
• Probability: 56.1%
• Matchup: USC Upstate vs. Fresno State (9:00PM ET, Wednesday)

Our model has identified value on under 164.5 points in USC Upstate vs. Fresno State at -105 odds. A 56.1% probability produces an edge of 4.9%, making this the strongest play for today's men's college basketball slate.

Fresno State -9.5 (-108)

• Edge: 2.8%
• Probability: 54.7%
• Matchup: USC Upstate vs. Fresno State (9:00PM ET, Wednesday)

Fresno State -9.5 carries a 2.8% edge and a probability of 54.7% at -108 odds, according to our model.

North Alabama +24.5 vs. Mississippi State(-102)

• Edge: 2.5%
• Probability: 53%
• Matchup: North Alabama vs. Mississippi State (9:00PM ET, Wednesday)

North Alabama +24.5 vs. Mississippi State at -102 odds shows a 2.5% edge, supported by a 53% probability in simulations.

Merrimack vs. Auburn over 145.5 points (-110)

• Edge: 4.4%
• Probability: 56.8%
• Matchup: Merrimack vs. Auburn (8:00PM ET, Thursday)

A 4.4% edge and 56.8% probability make Merrimack vs. Auburn over 145.5 points at a value play in the Merrimack vs. Auburn matchup, per our model.

Grambling State +33.5 (-104)

• Edge: 4.0%
• Probability: 55%
• Matchup: Grambling State vs. Iowa State (8:00PM ET, Thursday)

Grambling State +33.5 at -104 odds presents a 4.0% edge, with simulations resulting in a probability of 55%.

NCAAM best bets summary: Wednesday, 11/5/2025

As of 8:33PM ET, here are our top men's college basketball bets by edge recommended by our model:

List of upcoming men's college basketball games to bet on now

• North Dakota State vs. UC Davis (9:00PM ET, Wednesday)
• USC Upstate vs. Fresno State (9:00PM ET, Wednesday)
• North Alabama vs. Mississippi State (9:00PM ET, Wednesday)
• Eastern Washington vs. Loyola Marymount (10:30PM ET, Wednesday)
• Campbell vs. West Virginia (7:00PM ET, Thursday)
• Jackson State vs. Louisville (7:00PM ET, Thursday)
• Illinois State vs. Ohio (7:00PM ET, Thursday)
• Citadel vs. Boston College (7:00PM ET, Thursday)
• Bethune-Cookman vs. Miami (FL) (7:00PM ET, Thursday)
• Robert Morris vs. Drake (7:30PM ET, Thursday)

Conclusion

Our men's college basketball best bets are locked and loaded for November 5, 2025, featuring plays such as under 164.5 points in the USC Upstate vs. Fresno State matchup and Fresno State -9.5. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are sourced from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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