Men's college basketball picks today: Saturday's best bets highlight Northern Iowa vs. UC Irvine play [11/22/2025]

Today’s men's college basketball picks for November 22, 2025 are here, with Northern Iowa vs. UC Irvine among the top plays identified by our model across Saturday’s men's college basketball schedule.

Dimers’ predictive analytics engine runs 24/7, searching the latest men's college basketball odds to uncover top betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of NCAAM picks tonight [11/22, updated 8:35PM ET]

Below, you’ll find today’s top 10 men's college basketball bets, ranked by edge for Saturday, November 22, 2025.

UC Irvine ML (-142)

• Edge: 3.0%
• Probability: 61.6%
• Matchup: Northern Iowa vs. UC Irvine (10:30PM ET, Saturday)

Our model has identified value on UC Irvine to defeat Northern Iowa at -142 odds. A 61.6% probability produces an edge of 3.0%, making this the strongest play for today's men's college basketball slate.

Bryant University +36.5 (-104)

• Edge: 7.0%
• Probability: 58%
• Matchup: Bryant University vs. Connecticut (6:00PM ET, Sunday)

A 7.0% edge and 58% probability make Bryant University +36.5 vs. Connecticut at a value play in the Bryant University vs. Connecticut matchup, per our model.

Howard +39.5 (-104)

• Edge: 7.0%
• Probability: 58%
• Matchup: Howard vs. Duke (4:00PM ET, Sunday)

Howard +39.5 at -104 odds presents a 7.0% edge, with simulations resulting in a probability of 58%.

Butler vs. Virginia under 154.5 points (-105)

• Edge: 6.1%
• Probability: 57.3%
• Matchup: Butler vs. Virginia (2:00PM ET, Sunday)

Our model finds value on under 154.5 points in Butler vs. Virginia at -105 odds, supported by an edge of 6.1%.

Georgia +2.5 (-118)

• Edge: 3.8%
• Probability: 57.9%
• Matchup: Clemson vs. Georgia (1:00PM ET, Sunday) Our model has uncovered value on Georgia +2.5 at -118 odds. A 57.9% probability produces a 3.8% edge, making this a strong play for today's men's college basketball action.

Butler ML (+260)

• Edge: 3.6%
• Probability: 29.5%
• Matchup: Butler vs. Virginia (2:00PM ET, Sunday)

A 3.6% edge on a 29.5% probability makes Butler to win at +260 odds a solid value play in today's Butler vs. Virginia matchup.

UC Irvine ML (-142)

• Edge: 3.0%
• Probability: 61.6%
• Matchup: Northern Iowa vs. UC Irvine (10:30PM ET, Saturday)

Our model projects value on UC Irvine to win at -142 odds. A 61.6% probability produces a 3.0% edge, making UC Irvine the favorable ML play in Saturday’s matchup.

West Virginia vs. Xavier over 140.5 points (-110)

• Edge: 2.9%
• Probability: 55.2%
• Matchup: West Virginia vs. Xavier (3:30PM ET, Sunday)

Rounding out our top 10 bets, West Virginia vs. Xavier over 140.5 points at -110 odds shows a 55.2% probability and a 2.9% edge.

NCAAM best bets summary: Saturday, 11/22/2025

As of 8:35PM ET, here is our top men's college basketball bet by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Northern Iowa vs. UC Irvine	UC Irvine ML	-142 @ DraftKings	3.0%	61.6%
Bryant University vs. Connecticut	Bryant University +36.5	-104 @ FanDuel	7.0%	58%
Howard vs. Duke	Howard +39.5	-104 @ FanDuel	7.0%	58%
Butler vs. Virginia	Under 154.5 Points	-105 @ DraftKings	6.1%	57.3%
Clemson vs. Georgia	Georgia +2.5	-118 @ DraftKings	3.8%	57.9%
Butler vs. Virginia	Butler ML	+260 @ FanDuel	3.6%	29.5%
Northern Iowa vs. UC Irvine	UC Irvine ML	-142 @ DraftKings	3.0%	61.6%
West Virginia vs. Xavier	Over 140.5 Points	-110 @ DraftKings	2.9%	55.2%

List of upcoming men's college basketball games to bet on now

• Texas-Arlington vs. Weber State (9:00PM ET, Saturday)
• Northern Iowa vs. UC Irvine (10:30PM ET, Saturday)
• Clemson vs. Georgia (1:00PM ET, Sunday)
• Butler vs. Virginia (2:00PM ET, Sunday)
• Old Dominion vs. Drexel (2:00PM ET, Sunday)
• Alcorn State vs. Oklahoma (2:00PM ET, Sunday)
• Mount St. Mary's vs. Western Michigan (3:00PM ET, Sunday)
• Robert Morris vs. Monmouth (3:00PM ET, Sunday)
• West Virginia vs. Xavier (3:30PM ET, Sunday)
• Howard vs. Duke (4:00PM ET, Sunday)

Conclusion

Our men's college basketball best bets are locked and loaded for November 22, 2025, featuring plays such as UC Irvine ML. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college basketball insights quickly, with human oversight ensuring high editorial quality. Our predictions are rooted in current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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