Memphis vs. Wake Forest prediction: Why Wake Forest is favored to win men's college basketball matchup [11/21/2025]

Wake Forest will face Memphis in men's college basketball action at Baha Mar Convention Center on Friday, commencing at 7:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts Wake Forest as the most likely winner of the Memphis vs. Wake Forest game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Memphis vs. Wake Forest prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the result of Friday's NCAA basketball game between Memphis and Wake Forest 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Wake Forest a 59% chance of defeating Memphis. Our predicted final score has Wake Forest winning 80-78.

According to our model, Memphis (+3.5) has a 56% chance of covering the spread, while the 160.5-point over/under has a 53% chance of staying under.

Memphis vs. Wake Forest odds

We have researched the best Men's College Basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Memphis vs. Wake Forest picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Memphis +3.5 at the spread.

Memphis vs. Wake Forest game-day updates and essential details

Friday's men's college basketball matchup between Wake Forest and Memphis at Baha Mar Convention Center is scheduled to begin at 7:00PM ET.

• Who: Memphis vs. Wake Forest
• Date: Friday, November 21, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Baha Mar Convention Center

Conclusion

We predict Wake Forest, with a 59% win probability, will likely beat Memphis on Friday.

AI and automation have enhanced this article to quickly deliver accurate Memphis vs. Wake Forest insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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