Marquette vs. DePaul prediction: DePaul favored to win men's college basketball matchup [1/16/2026]

DePaul will take on Marquette in men's college basketball action at Wintrust Arena on Friday, commencing at 8:30 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts DePaul as the most likely winner of the Marquette vs. DePaul game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Marquette vs. DePaul prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Friday's NCAA basketball game between Marquette and DePaul 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives DePaul a 63% chance of defeating Marquette. Our predicted final score has DePaul winning 74-71.

According to our model, the bookmakers have got it right, and Marquette and DePaul each have a 50% chance of covering the spread, while the 144.5-point over/under has a 53% chance of going over.

Marquette vs. DePaul odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Marquette vs. DePaul picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: