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LSU vs. Duke prediction: LSU favored to win women's college basketball matchup [12/4/2025]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get LSU vs Duke predictions for college basketball Thursday.
Duke and LSU will lock horns in the women's college basketball at Cameron Indoor Stadium on Thursday, starting at 9:00PM ET.
Based on the latest simulations, Dimers' new women's basketball model predicts LSU as the most likely winner of the LSU vs. Duke game.
This article offers an expanded analysis of Thursday's matchup, including best bets and picks.
LSU vs. Duke prediction: Who will win?
Using trusted machine learning and data, we have simulated the outcome of Thursday's women's basketball game between LSU and Duke 10,000 times as part of our women's college basketball predictions coverage.
Our independent predictive model currently gives LSU a 75% chance of beating Duke.
According to our model, the over/under total of 148.5 points has a 63% chance of staying under.
LSU vs. Duke odds
We have sourced the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | LSU | Duke |
|---|---|---|
| Spread | -15.5 (-115) | +15.5 (-105) |
| Moneyline | -2083 | +1200 |
| Total | o148.5 (-108) | u148.5 (-110) |
All odds are correct at the time of publication and are subject to change.
LSU vs. Duke picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Duke +15.5 | -105 |
| Moneyline | Duke | +1200 |
| Total | Under 148.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is Duke to win.
LSU vs. Duke game-day updates and essential details
Thursday's women's basketball action between Duke and LSU at Cameron Indoor Stadium is scheduled to commence at 9:00PM ET.
- Who: LSU vs. Duke
- Date: Thursday, December 4, 2025
- Time: 9:00PM ET/6:00PM PT
- Venue: Cameron Indoor Stadium
Conclusion
We predict LSU, with a 75% win probability, will likely beat Duke on Thursday.
AI and automation have enhanced this article to quickly deliver accurate LSU vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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