Loyola Chicago vs. San Francisco prediction: San Francisco favored to win men's college basketball matchup [12/17/2025]

San Francisco and Loyola Chicago will meet in men's college basketball action at Chase Center on Wednesday, starting at 10:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model projects San Francisco as the most likely winner of the Loyola Chicago vs. San Francisco game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Loyola Chicago vs. San Francisco prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball game between Loyola Chicago and San Francisco 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives San Francisco a 92% chance of defeating Loyola Chicago. Our predicted final score has San Francisco winning 79-64.

According to our model, San Francisco (-12.5) has a 57% chance of covering the spread, while the 142.5-point over/under has a 53% chance of going over.

Loyola Chicago vs. San Francisco odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Loyola Chicago vs. San Francisco picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: