Louisville vs. Wake Forest prediction: Why Louisville is favored to win men's college basketball matchup [2/7/2026]

Wake Forest will square off with the favored Louisville in men's college basketball action at Lawrence Joel Veterans Memorial Coliseum on Saturday, commencing at 12:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Louisville as the most likely winner of the Louisville vs. Wake Forest game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisville vs. Wake Forest prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Saturday's NCAA basketball matchup between Louisville and Wake Forest 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Louisville a 79% chance of defeating Wake Forest. Our predicted final score has Louisville winning 82-73.

According to our model, Wake Forest (+9.5) has a 51% chance of covering the spread, while the over/under total of 160.5 points has a 53% chance of staying under.

Louisville vs. Wake Forest odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisville vs. Wake Forest picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: