Louisville vs. Pittsburgh prediction: Why Louisville is favored to win men's college basketball matchup [1/17/2026]

Men's college basketball action continues on Saturday at 8:00 PM ET as the favored Louisville locks horns with Pittsburgh in men's college basketball action at Petersen Events Center.

Based on updated simulations, Dimers' proven college basketball model projects Louisville as the most likely winner of the Louisville vs. Pittsburgh game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Louisville vs. Pittsburgh prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball matchup between Louisville and Pittsburgh 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Louisville a 73% chance of defeating Pittsburgh. Our predicted final score has Louisville winning 77-71.

According to our model, Pittsburgh (+7.5) has a 55% chance of covering the spread, while the over/under total of 151.5 points has a 55% chance of staying under.

Louisville vs. Pittsburgh odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Louisville vs. Pittsburgh picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: