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Louisville vs. Duke prediction: Duke favored to win men's college basketball matchup [1/26/2026]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Louisville vs Duke predictions for college basketball Monday.
Duke and Louisville will lock horns in men's college basketball action at Cameron Indoor Stadium on Monday, starting at 7:00 PM ET.
Based on the latest simulations, Dimers' proven college basketball model predicts Duke as the most likely winner of the Louisville vs. Duke game.
This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.
Louisville vs. Duke prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Monday's NCAA basketball game between Louisville and Duke 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Duke a 76% chance of defeating Louisville. Our predicted final score has Duke winning 83-75.
According to our model, Louisville (+8.5) has a 51% chance of covering the spread, while the over/under total of 157.5 points has a 52% chance of going over.
Louisville vs. Duke odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Louisville | Duke |
|---|---|---|
| Spread | +8.5 (-110) | -8.5 (-110) |
| Moneyline | +365 | -450 |
| Total | o157.5 (-105) | u157.5 (-114) |
All odds are correct at the time of publication and are subject to change.
Louisville vs. Duke picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Louisville +8.5 | -110 |
| Moneyline | Louisville | +365 |
| Total | Over 157.5 | -105 |
According to our men's college basketball best bets, the top play to make on this game is Louisville to win.
Louisville vs. Duke game-day updates and essential details
Monday's men's college basketball game between Duke and Louisville at Cameron Indoor Stadium is scheduled to commence at 7:00 PM ET.
- Who: Louisville vs. Duke
- Date: Monday, January 26, 2026
- Time: 7:00 PM ET/4:00PM PT
- Venue: Cameron Indoor Stadium
Conclusion
We predict Duke, with a 76% win probability, will likely beat Louisville on Monday.
AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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